IKBKE and XIAP

Number of citations of the paper that reports this interaction (PubMedID 22072751)
69

Data Source:
BioGRID (enzymatic study)

		IKBKE	XIAP
Description		inhibitor of nuclear factor kappa B kinase subunit epsilon	X-linked inhibitor of apoptosis
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane Serine/threonine Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Peptidase Inhibitor Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Activation Of Innate Immune Response Response To Stress Immune Response DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Positive Regulation Of Type I Interferon Production Response To Cytokine Response To Type I Interferon Response To Interferon-beta Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly MRNA Stabilization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Protein Linear Polyubiquitination Execution Phase Of Apoptosis Positive Regulation Of Protein Linear Polyubiquitination
Pathways		SUMOylation of immune response proteins TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity
Drugs		Fostamatinib	1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156 Terpinen-4-ol
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP	105 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CAD CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 EEF2 ERCC3 FAF1 FLNA FLNB GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSP90AB1 HSPA1A HTRA1 HTRA2 HTRA3 IKBKE INPP5D KCNJ6 LIMA1 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NCOA6 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 OGT PGAM5 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK3 RIPK4 RPS9 RUNX1T1 SDHA SEPTIN4 SERPINA12 SERTAD1 SSX2IP STRADB STUB1 SYNE1 TAB1 TAB2 TBK1 TGFBR1 TPM3 TRAF6 TRIM32 TRIM8 TTC23 TUFM UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2L3 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1
Entrez ID		9641	331
HPRD ID		05442	02094
Ensembl ID		ENSG00000263528	ENSG00000101966
Uniprot IDs		A0A075B7B4 Q14164	B2R9R2 P98170
PDB IDs			1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI 8AZA 8GH7 8W59 8W5A
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Regulation Of Post-translational Protein Modification Regulation Of Defense Response Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To External Biotic Stimulus Innate Immune Response-activating Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Response To Stress Response To Virus Regulation Of Apoptotic Process Regulation Of Immune Response Activation Of Immune Response Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Ubiquitination Intracellular Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Response To Other Organism Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Canonical NF-kappaB Signal Transduction	Protein Metabolic Process Protein Modification Process Protein Polyubiquitination Cytosol Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Signal Transduction Nucleotide Binding Programmed Cell Death Cell Death Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification ATP Binding Protein Ubiquitination Ubiquitin Protein Ligase Binding Cytoplasm Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Protein Modification By Small Protein Conjugation Apoptotic Process Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Signal Transduction Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Transferase Activity Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway
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