GNA14 and CXCR1

Number of citations: 0 (PubMedID 8316840)
Data Source: HPRD (in vitro)

		GNA14	CXCR1
Name		G protein subunit alpha 14	C-X-C motif chemokine receptor 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Action Potential Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Phospholipase C-activating Dopamine Receptor Signaling Pathway	Dendritic Cell Chemotaxis Chemotaxis Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		None	Ketoprofen
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Bipolar disorder ( 31043756 ) Delirium ( 29631748 ) Thoracic aortic calcification levels ( 31659325 )	Basophil count ( 32888494 ) Diffusing capacity of carbon monoxide ( 30694715 ) Idiopathic intracranial hypertension ( 29608535 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil count ( 29403010 ) Smooth-surface caries ( 23470693 ) White blood cell count ( 29403010 )
Novel Interactors		None recorded	1 novel interactors: TUBA4A
Interacting Genes		9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2	20 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C
Entrez ID		9630	3577
HPRD ID		05095	00908
Ensembl ID		ENSG00000156049	ENSG00000163464
Uniprot IDs		O95837	P25024
PDB IDs		Not available	1ILP 1ILQ 2LNL 6XMN 8IC0
GO Terms Enriched among Interactors		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Dendritic Cell Chemotaxis Chemokine Receptor Activity Dendritic Cell Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Interleukin-8 Binding Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane C-X-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Receptor-mediated Endocytosis Signal Transduction Vesicle-mediated Transport Cell Chemotaxis Import Into Cell Leukocyte Migration Neutrophil Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Chemotaxis Neutrophil Migration Nociceptin Receptor Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Intracellular Signaling Cassette External Side Of Plasma Membrane Locomotion Granulocyte Chemotaxis Regulation Of Bone Mineralization Beta2-adrenergic Receptor Activity	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Antimicrobial Humoral Response Granulocyte Migration CXCR Chemokine Receptor Binding Chemotaxis Cytokine Activity Locomotion Inflammatory Response Myeloid Leukocyte Migration Leukocyte Chemotaxis Humoral Immune Response Cell Migration Cell Motility Leukocyte Migration Killing Of Cells Of Another Organism Guanyl Nucleotide Binding G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Cell Killing Neutrophil Activation Heterotrimeric G-protein Complex Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Defense Response Defense Response To Symbiont Defense Response To Other Organism Response To Molecule Of Bacterial Origin Immune Response Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide GTP Binding Extracellular Region Cellular Response To Molecule Of Bacterial Origin G Protein-coupled Receptor Binding Protein Polymerization Cell Division Extracellular Space Response To Other Organism Microtubule Polymerization G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Lipopolysaccharide Myeloid Leukocyte Activation D-glucose Transmembrane Transport Response To External Biotic Stimulus