CXCR1 and UBE2C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CXCR1	UBE2C
Gene Name		chemokine (C-X-C motif) receptor 1	ubiquitin-conjugating enzyme E2C
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	Interleukin-8 Receptor Activity G-protein Coupled Receptor Activity Chemokine Receptor Activity Interleukin-8 Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Exit From Mitosis Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)
Protein-Protein Interactions		16 interactors: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	20 interactors: ANAPC11 ANAPC2 CDC20 CKAP2 CXCR1 DTX1 ENO2 FZR1 KLHL2 MAPK7 PCGF3 POLM PSMD4 RELA TNNC1 TRIM21 TRIM28 UBA1 UBASH3B UBE3D
Entrez ID		3577	11065
HPRD ID		00908	05717
Ensembl ID		ENSG00000163464	ENSG00000175063
Uniprot IDs		P25024	O00762 Q5TZN3
PDB IDs		1ILP 1ILQ 2LNL	1I7K
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Inflammatory Response Response To Cytokine Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Bacterium Locomotion Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Organic Substance Response To Organic Substance Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Movement Of Cell Or Subcellular Component Response To Other Organism Response To Biotic Stimulus Response To Lipid Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Polyubiquitination Negative Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Positive Regulation Of Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Mitotic Spindle Checkpoint Cellular Protein Metabolic Process Negative Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Protein Metabolic Process Activation Of Anaphase-promoting Complex Activity
Tagcloud ?		ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	accelerated amplifications cin conferring connection copy core decipher disadvantage drive fitness framework genomes instability intratumor intriguingly landscape logical module permissive permits pressures regulators selection sets signature signatures tpx2 typically
Tagcloud (Difference) ?		ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	accelerated amplifications cin conferring connection copy core decipher disadvantage drive fitness framework genomes instability intratumor intriguingly landscape logical module permissive permits pressures regulators selection sets signature signatures tpx2 typically
Tagcloud (Intersection) ?