GNA14 and DNAL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GNA14	DNAL4
Description		G protein subunit alpha 14	dynein axonemal light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Action Potential Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Phospholipase C-activating Dopamine Receptor Signaling Pathway	Microtubule-based Process Microtubule-based Movement
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 31043756) Delirium ( 29631748) Thoracic aortic calcification levels ( 31659325)
Interacting Genes		9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2	14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54
Entrez ID		9630	10126
HPRD ID		05095	13239
Ensembl ID		ENSG00000156049	ENSG00000100246
Uniprot IDs		O95837	O96015
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Dendritic Cell Chemotaxis Chemokine Receptor Activity Dendritic Cell Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Interleukin-8 Binding Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane C-X-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Receptor-mediated Endocytosis Signal Transduction Vesicle-mediated Transport Cell Chemotaxis Import Into Cell Leukocyte Migration Neutrophil Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Chemotaxis Neutrophil Migration Nociceptin Receptor Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Intracellular Signaling Cassette External Side Of Plasma Membrane Locomotion Granulocyte Chemotaxis Regulation Of Bone Mineralization Beta2-adrenergic Receptor Activity
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