CXCR1 and CXCL3

Number of citations of the paper that reports this interaction (PMID 8702798)
57

Data Source:
HPRD (in vivo, in vitro)

		CXCR1	CXCL3
Gene Name		chemokine (C-X-C motif) receptor 1	chemokine (C-X-C motif) ligand 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G-protein Coupled Receptor Activity Chemokine Receptor Activity Interleukin-8 Binding	Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway	Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Cell Proliferation Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		16 interactors: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	2 interactors: CXCR1 CXCR2
Entrez ID		3577	2921
HPRD ID		00908	00742
Ensembl ID		ENSG00000163464	ENSG00000163734
Uniprot IDs		P25024	P19876
PDB IDs		1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Inflammatory Response Response To Cytokine Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Bacterium Locomotion Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Organic Substance Response To Organic Substance Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Movement Of Cell Or Subcellular Component Response To Other Organism Response To Biotic Stimulus Response To Lipid Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Interleukin-8-mediated Signaling Pathway Dendritic Cell Chemotaxis Dendritic Cell Migration Receptor Internalization Chemokine-mediated Signaling Pathway Receptor Metabolic Process Leukocyte Chemotaxis Cell Chemotaxis Negative Regulation Of Neutrophil Apoptotic Process Leukocyte Migration Receptor-mediated Endocytosis Inflammatory Response Cytokine-mediated Signaling Pathway Acute Inflammatory Response To Antigenic Stimulus Cellular Response To Cytokine Stimulus Chemotaxis Positive Regulation Of Vascular Permeability Endocytosis Metanephric Tubule Morphogenesis Response To Cytokine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Negative Regulation Of Myeloid Cell Apoptotic Process Cell Motility Positive Regulation Of Neutrophil Chemotaxis Neutrophil Activation Positive Regulation Of Granulocyte Chemotaxis Regulation Of Neutrophil Chemotaxis Metanephric Epithelium Development Regulation Of Neutrophil Migration Regulation Of Vascular Permeability G-protein Coupled Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Regulation Of Granulocyte Chemotaxis Locomotion Regulation Of Myeloid Cell Apoptotic Process Defense Response Vesicle-mediated Transport Neutrophil Chemotaxis Movement Of Cell Or Subcellular Component Neutrophil Migration Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Muscle Cell Apoptotic Process Cellular Defense Response Granulocyte Chemotaxis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Response To External Stimulus Acute Inflammatory Response Cellular Response To Organic Substance
Tagcloud ?		ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	1beta a549 alveolar array cc ccl2 ccl5 chemokine chemokines clearly cxcl1 cxcl11 cxcl2 cxcl5 cxcl6 cxcl8 cytokines elisa epithelial immunoluminometric multiplex overlapping repetitive share signalling similarities stimulate supernatants
Tagcloud (Difference) ?		ab attenuating chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	1beta a549 alveolar array cc ccl2 ccl5 clearly cxcl1 cxcl11 cxcl2 cxcl5 cxcl6 cxcl8 cytokines elisa epithelial immunoluminometric multiplex overlapping repetitive share signalling similarities stimulate supernatants
Tagcloud (Intersection) ?		chemokine chemokines