CXCR1

Name	C-X-C motif chemokine receptor 1
Structure
Novel Interactors	1 novel interactors: TUBA4A
Interactors	20 interactors: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway
Pathways	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs	Ketoprofen
GWAS	Basophil count ( 32888494 ) Diffusing capacity of carbon monoxide ( 30694715 ) Idiopathic intracranial hypertension ( 29608535 ) Inflammatory bowel disease ( 23128233 28067908 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil count ( 29403010 ) Smooth-surface caries ( 23470693 ) White blood cell count ( 29403010 )
Entrez ID	3577
HPRD ID	00908
Ensembl ID	ENSG00000163464
Uniprot IDs	P25024
PDB IDs	1ILP 1ILQ 2LNL 6XMN 8IC0
GO Terms Enriched among Interactors ?	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Antimicrobial Humoral Response Granulocyte Migration CXCR Chemokine Receptor Binding Chemotaxis Cytokine Activity Locomotion Inflammatory Response Myeloid Leukocyte Migration Leukocyte Chemotaxis Humoral Immune Response Cell Migration Cell Motility Leukocyte Migration Killing Of Cells Of Another Organism Guanyl Nucleotide Binding G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Cell Killing Neutrophil Activation Heterotrimeric G-protein Complex Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Defense Response Defense Response To Symbiont Defense Response To Other Organism Response To Molecule Of Bacterial Origin Immune Response Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide GTP Binding Extracellular Region Cellular Response To Molecule Of Bacterial Origin G Protein-coupled Receptor Binding Protein Polymerization Cell Division Extracellular Space Response To Other Organism Microtubule Polymerization G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Lipopolysaccharide Myeloid Leukocyte Activation D-glucose Transmembrane Transport Response To External Biotic Stimulus