CXCR1 and TRARG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCR1	TRARG1
Description		C-X-C motif chemokine receptor 1	trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Cytoplasm Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway	Cellular Response To Insulin Stimulus Glucose Import In Response To Insulin Stimulus Establishment Of Localization In Cell Protein Localization To Plasma Membrane Vesicle Fusion To Plasma Membrane Endosome To Plasma Membrane Protein Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		Ketoprofen
Diseases
GWAS		Basophil count ( 32888494) Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		20 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A UBE2C	102 interacting genes: APH1A APH1B AQP12B AQP2 ARL13B BCL2L13 BIK BSCL2 C6orf89 CARINH CCR4 CD300E CD53 CD79A CLDN12 CLDN7 CLDN8 CLEC10A CXCR1 CXCR2 DAGLA EBP EFNA4 ELOVL4 ERGIC3 FAM209A FNDC9 FUT3 GJB3 GPR151 GPR42 GPR61 GPRC5D HSF2BP IFNGR2 IL3RA KASH5 KCNC1 KRT34 KRTAP5-9 LAPTM4B LHFPL5 LY6E MEOX2 MFF MRM1 MRPS18B MTIF3 NPFFR2 NPY2R ODF4 OPN1LW OPRM1 OR7D4 OSTC PDZK1IP1 PLEKHB2 PSCA RHBDL1 RHCG RTP4 SCN3B SDCBP SLC10A1 SLC10A6 SLC13A4 SLC14A2 SLC16A2 SLC1A5 SLC30A2 SLC34A2 SLC35F1 SLC36A1 SLC38A1 SLC38A11 SLC38A6 SLC39A1 SLC71A2 SLC7A1 SLC7A14 SLCO3A1 SPAG4 SSMEM1 SYNPR TAAR9 TM4SF18 TMC4 TMEM179B TMEM237 TMEM248 TMEM31 TMEM45A TMEM52B TMEM69 TMEM71 TMEM80 TMEM9 TMPPE TTYH2 WFS1 YIPF6 ZDHHC4
Entrez ID		3577	286753
HPRD ID		00908	18248
Ensembl ID		ENSG00000163464	ENSG00000184811
Uniprot IDs		P25024	Q8IXB3
PDB IDs		1ILP 1ILQ 2LNL 6XMN 8IC0
Enriched GO Terms of Interacting Partners?		Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Chemotaxis Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis Antimicrobial Humoral Response Granulocyte Migration CXCR Chemokine Receptor Binding Chemotaxis Cytokine Activity Locomotion Inflammatory Response Myeloid Leukocyte Migration Leukocyte Chemotaxis Humoral Immune Response Cell Migration Cell Motility Leukocyte Migration Killing Of Cells Of Another Organism Guanyl Nucleotide Binding G Protein-coupled Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Cell Killing Neutrophil Activation Heterotrimeric G-protein Complex Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Defense Response Defense Response To Symbiont Defense Response To Other Organism Response To Molecule Of Bacterial Origin Immune Response Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide GTP Binding Extracellular Region Cellular Response To Molecule Of Bacterial Origin G Protein-coupled Receptor Binding Protein Polymerization Cell Division Extracellular Space Response To Other Organism Microtubule Polymerization G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Cell Population Proliferation Response To Lipopolysaccharide Myeloid Leukocyte Activation D-glucose Transmembrane Transport Response To External Biotic Stimulus	Membrane Plasma Membrane Transmembrane Transport Amino Acid Transmembrane Transport Protein Binding Amino Acid Transmembrane Transporter Activity Amino Acid Transport Carboxylic Acid Transport Organic Acid Transport L-amino Acid Transport G Protein-coupled Receptor Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Organic Anion Transport L-alpha-amino Acid Transmembrane Transport Symporter Activity Amino Acid Import Across Plasma Membrane L-glutamine Transmembrane Transporter Activity Glutamine Transport Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Apical Plasma Membrane Monoatomic Ion Transport Basolateral Plasma Membrane Interleukin-8 Binding Sodium Ion Transport Transport Across Blood-brain Barrier Neutral L-amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transport Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity L-glutamine Import Across Plasma Membrane Bile Acid:sodium Symporter Activity Transmembrane Transporter Activity Gamma-secretase Complex G Protein-coupled Receptor Signaling Pathway Metal Ion Transport Inorganic Ion Transmembrane Transport C-X-C Chemokine Receptor Activity Notch Receptor Processing
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