CXCR1 and CXCL1

Number of citations of the paper that reports this interaction (PMID 8702798)
57

Data Source:
HPRD (in vivo)

		CXCR1	CXCL1
Gene Name		chemokine (C-X-C motif) receptor 1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G-protein Coupled Receptor Activity Chemokine Receptor Activity Interleukin-8 Binding	Receptor Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Receptor Internalization Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Actin Cytoskeleton Organization Response To Lipopolysaccharide Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Smooth-surface caries ( 23470693)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		16 interactors: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	5 interactors: ACKR1 CXCR1 CXCR2 HIPK2 MMP9
Entrez ID		3577	2919
HPRD ID		00908	01119
Ensembl ID		ENSG00000163464	ENSG00000163739
Uniprot IDs		P25024	P09341
PDB IDs		1ILP 1ILQ 2LNL	1MGS 1MSG 1MSH 1ROD
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Chemotaxis Regulation Of Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Inflammatory Response Response To Cytokine Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Lipopolysaccharide Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Bacterium Locomotion Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Organic Substance Response To Organic Substance Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Stress Movement Of Cell Or Subcellular Component Response To Other Organism Response To Biotic Stimulus Response To Lipid Signal Transduction Cellular Response To Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Interleukin-8-mediated Signaling Pathway Chemokine-mediated Signaling Pathway Dendritic Cell Chemotaxis Leukocyte Migration Dendritic Cell Migration Receptor Internalization Cell Surface Receptor Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Binding Receptor Metabolic Process Cellular Response To Cytokine Stimulus Chemotaxis Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Neutrophil Apoptotic Process Response To Cytokine Positive Regulation Of Binding Positive Regulation Of Angiogenesis Immune System Process Regulation Of Protein Binding Cell Migration Cell Chemotaxis Cell Motility Signal Transduction Response To Organic Substance Signaling Positive Regulation Of Receptor Binding Voluntary Musculoskeletal Movement Regulation Of Angiogenesis Cell Communication Positive Regulation Of Keratinocyte Migration PML Body Organization Myeloid Cell Differentiation G-protein Coupled Receptor Signaling Pathway Regulation Of Binding Acute Inflammatory Response To Antigenic Stimulus Locomotion Defense Response Iris Morphogenesis Cellular Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Lens Induction In Camera-type Eye Metanephric Tubule Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Locomotion
Tagcloud ?		ab attenuating chemokine chemokines chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	backgroundmonocyte ccl3 ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Difference) ?		ab attenuating chemokine chemotactic cxcr2 defenses distress donors ena express fmlp functionally ligands migratory milieu neutrophil neutrophils observations offer oncogene persisted pmn polymorphonuclear preserving redundant sepsis septic	backgroundmonocyte ccl3 ccl4 ccl7 cd45 conclusionsour contrasted contributors degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Intersection) ?		chemokines