GNA14 and CHRM2

Number of citations of the paper that reports this interaction (PubMedID 7797501)
0

Data Source:
HPRD (in vivo)

		GNA14	CHRM2
Description		G protein subunit alpha 14	cholinergic receptor muscarinic 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome	Nucleolus Golgi Apparatus Plasma Membrane Cilium Membrane Dendrite Clathrin-coated Endocytic Vesicle Membrane Ciliary Basal Body Synapse Postsynaptic Membrane Presynapse Cholinergic Synapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Arrestin Family Protein Binding
	Biological Process	Action Potential Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Phospholipase C-activating Dopamine Receptor Signaling Pathway	Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Regulation Of Heart Contraction Response To Virus Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Profenamine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Gallamine triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine methylbromide Nortriptyline Amoxapine Cisatracurium Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Rocuronium Scopolamine Benzquinamide Propiomazine Cryptenamine Dicyclomine Tropicamide Brompheniramine Cocaine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Diphenhydramine Pilocarpine Doxacurium Doxepin Flavoxate Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Metocurine Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Acetylcholine Rapacuronium ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Dimetindene Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 31043756) Delirium ( 29631748) Thoracic aortic calcification levels ( 31659325)	Copper levels ( 26025379) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) PR interval ( 32439900) Pulse pressure ( 30224653) Resting heart rate ( 27798624 29769521)
Interacting Genes		9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2	18 interacting genes: GJC2 GNA11 GNA14 GNA15 GNG2 GPRASP1 GPRASP2 GRK5 HERPUD1 MDH1 RGS7 SAG SET SHISA4 SLC52A2 TMEM8B TSPAN33 TSPAN7
Entrez ID		9630	1129
HPRD ID		05095	00328
Ensembl ID		ENSG00000156049	ENSG00000181072
Uniprot IDs		O95837	A4D1Q0 P08172 Q6SL56 Q6SL59 Q86SJ1
PDB IDs			3UON 4MQS 4MQT 5YC8 5ZK3 5ZK8 5ZKB 5ZKC 6OIK 6U1N 7T8X 7T90 7T94 7T96 8J8R 8J97 8JAF
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Dendritic Cell Chemotaxis Chemokine Receptor Activity Dendritic Cell Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Interleukin-8 Binding Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane C-X-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Receptor-mediated Endocytosis Signal Transduction Vesicle-mediated Transport Cell Chemotaxis Import Into Cell Leukocyte Migration Neutrophil Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Chemotaxis Neutrophil Migration Nociceptin Receptor Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Intracellular Signaling Cassette External Side Of Plasma Membrane Locomotion Granulocyte Chemotaxis Regulation Of Bone Mineralization Beta2-adrenergic Receptor Activity	G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Phototransduction Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity Protein Phosphatase Inhibitor Activity 4-hydroxybutyrate Receptor Activity Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Detection Of Light Stimulus Plasma Membrane G Protein-coupled Receptor Catabolic Process Photoreceptor Outer Segment
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