GNA14 and OPRL1

Number of citations of the paper that reports this interaction (PubMedID 9862775)
0

Data Source:
HPRD (in vitro, in vivo)

		GNA14	OPRL1
Description		G protein subunit alpha 14	opioid related nociceptin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome	Plasma Membrane Membrane Cytoplasmic Vesicle Neuron Projection Synaptic Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Nociceptin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Neuropeptide Binding
	Biological Process	Action Potential Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Inflammatory Response Phospholipase C-activating Dopamine Receptor Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Neuron-neuron Synaptic Transmission Sensory Perception Sensory Perception Of Pain Calcium-mediated Signaling G Protein-coupled Opioid Receptor Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 31043756) Delirium ( 29631748) Thoracic aortic calcification levels ( 31659325)	A body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2	10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
Entrez ID		9630	4987
HPRD ID		05095	03971
Ensembl ID		ENSG00000156049	ENSG00000125510
Uniprot IDs		O95837	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs			4EA3 5DHG 5DHH 8F7X
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Dendritic Cell Chemotaxis Chemokine Receptor Activity Dendritic Cell Migration C-C Chemokine Binding C-C Chemokine Receptor Activity Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Interleukin-8 Binding Calcium-mediated Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane C-X-C Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Receptor-mediated Endocytosis Signal Transduction Vesicle-mediated Transport Cell Chemotaxis Import Into Cell Leukocyte Migration Neutrophil Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Chemotaxis Neutrophil Migration Nociceptin Receptor Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Intracellular Signaling Cassette External Side Of Plasma Membrane Locomotion Granulocyte Chemotaxis Regulation Of Bone Mineralization Beta2-adrenergic Receptor Activity	Regulation Of Copper Ion Transmembrane Transport TAP Binding Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity Cellular Response To Morphine Morphine Receptor Activity Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Opioid Receptor Binding Opioid Peptide Activity G Protein-coupled Receptor Catabolic Process Regulation Of Transcytosis Compact Myelin Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport Positive Regulation Of Oligodendrocyte Apoptotic Process Receptor Ligand Activity
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