ARHGAP32 and LHX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGAP32	LHX2
Description		Rho GTPase activating protein 32	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Membrane Cell Projection Dendritic Spine Synapse	Chromatin Nucleus
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Neural Tube Closure Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Brain Development Mesoderm Development Dorsal/ventral Pattern Formation Telencephalon Development Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neurogenesis Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Regulation of expression of SLITs and ROBOs Expression and translocation of olfactory receptors
Drugs
Diseases
GWAS		Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000) Refractive error ( 32231278)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5	30 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 NFIA NFIB NFIC OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		9743	9355
HPRD ID		12257	04786
Ensembl ID		ENSG00000134909	ENSG00000106689
Uniprot IDs		A0A804HK06 A7KAX9	B3KNJ5 P50458
PDB IDs		3IUG
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Cell Surface Receptor Signaling Pathway Cell Motility Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Signal Transduction Cell-cell Junction Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Developmental Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Ephrin Receptor Binding Lamellipodium Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Protein Kinase Binding Signaling Adaptor Activity Neuron Migration Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Actin Filament Organization Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Regulation Of Locomotion Cell-cell Junction Organization Regulation Of Lamellipodium Organization Cell Projection Organization	Glial Cell Fate Specification Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retina Development In Camera-type Eye Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Gene Expression Forebrain Development Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Exit From Mitosis Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Biosynthetic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Synapse Maturation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription BMP Signaling Pathway Response To Wounding Sequence-specific Double-stranded DNA Binding Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Regulation Of Primary Metabolic Process Generation Of Neurons Regulation Of Macromolecule Metabolic Process Neural Precursor Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex DNA-templated Transcription Histone Acetyltransferase Binding Embryonic Eye Morphogenesis
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