ARHGAP32 and SHC3

Number of citations of the paper that reports this interaction (PubMedID 12446789)
62

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		ARHGAP32	SHC3
Description		Rho GTPase activating protein 32	SHC adaptor protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Fibrillar Center Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Membrane Cell Projection Dendritic Spine Synapse	Cytosol Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding	Phosphotyrosine Residue Binding Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Intracellular Signal Transduction
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000) Refractive error ( 32231278)	Femur bone mineral density x serum urate levels interaction ( 34046847) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte count ( 32888494) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to statins (LDL cholesterol change) ( 22331829) Superior parietal cortex volume ( 31530798) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5	58 interacting genes: ALK ANKRD10 APP AR ARHGAP32 ASPG AXL BMF CCNC CDCA4 CEACAM6 COPS6 CT55 DOK3 EGFR ERBB2 ERBB3 ERBB4 FLT4 FTO GAB1 GOLGA2 GOLGA6L9 GRB2 KIT KRT31 KRT33B KRT34 KRT35 KRT39 KRT40 KRT86 MET NTRK1 NTRK2 PMF1 PNMA1 PPP1R16B PRKAR1B PSMD8 REL RET SH3GL3 SMYD3 STX11 TRAF1 TRAF2 TRIM35 TRIM54 TSC1 UBAP2 USHBP1 USP54 VPS28 WWOX YPEL3 YPEL5 ZMYND12
Entrez ID		9743	53358
HPRD ID		12257	12005
Ensembl ID		ENSG00000134909	ENSG00000148082
Uniprot IDs		A0A804HK06 A7KAX9	Q92529
PDB IDs		3IUG
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Cell Surface Receptor Signaling Pathway Cell Motility Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Signal Transduction Cell-cell Junction Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Developmental Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Ephrin Receptor Binding Lamellipodium Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Protein Kinase Binding Signaling Adaptor Activity Neuron Migration Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Actin Filament Organization Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Regulation Of Locomotion Cell-cell Junction Organization Regulation Of Lamellipodium Organization Cell Projection Organization	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Structural Constituent Of Skin Epidermis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity Tissue Morphogenesis Regulation Of Apoptotic Process Morphogenesis Of An Epithelium Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade ERBB Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Kinase Activity ERBB2 Signaling Pathway Intermediate Filament Cellular Developmental Process Basal Plasma Membrane Positive Regulation Of Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Response To Growth Factor ERBB3:ERBB2 Complex Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Protein Phosphatase Binding Growth Factor Binding Myelination Anatomical Structure Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Axon Ensheathment Neuron Differentiation System Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?