SH2D3C and EPHB2

Number of citations of the paper that reports this interaction (PMID 10542222)
28

Data Source:
HPRD (in vitro)

		SH2D3C	EPHB2
Gene Name		SH2 domain containing 3C	EPH receptor B2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways			EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BCAR1 CARD11 EFS EPHB2 MAPK1 NEDD9 PTK2B SNCAIP SRC	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		10044	2048
HPRD ID		05284	02997
Ensembl ID		ENSG00000095370	ENSG00000133216
Uniprot IDs		B4DG32 E7EUN5 Q8N5H7	P29323
PDB IDs		3T6G	1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Adhesion Actin Filament Bundle Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport T Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Signal Complex Assembly Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epithelial Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Body Fluid Levels Signal Transduction Regulation Of Cell Migration Locomotion Platelet Activation Chemotaxis Actin Cytoskeleton Organization Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Immune Response Actin Filament-based Process Bone Resorption Neurotrophin Signaling Pathway Signaling Regulation Of Locomotion Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Component Movement Cell Communication Cell Proliferation B Cell Receptor Signaling Pathway	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?