SH2D3C and CARD11

Number of citations of the paper that reports this interaction (PMID 16825666)
14

Data Source:
HPRD (in vivo)

		SH2D3C	CARD11
Gene Name		SH2 domain containing 3C	caspase recruitment domain family, member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane T Cell Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Guanylate Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	JNK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Positive Regulation Of Cytokine Production Positive Regulation Of B Cell Proliferation T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation Nucleotide Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Atopic dermatitis ( 23042114) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Protein-Protein Interactions		9 interactors: BCAR1 CARD11 EFS EPHB2 MAPK1 NEDD9 PTK2B SNCAIP SRC	10 interactors: BCL10 IKBKG MAP3K7 PDPK1 PRKCB PRKCQ SH2D3C TAB1 WDR1 ZAP70
Entrez ID		10044	84433
HPRD ID		05284	06234
Ensembl ID		ENSG00000095370	ENSG00000198286
Uniprot IDs		B4DG32 E7EUN5 Q8N5H7	Q8TES3 Q9BXL7
PDB IDs		3T6G
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Adhesion Actin Filament Bundle Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Stress Fiber Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport T Cell Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Signal Complex Assembly Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Epithelial Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Body Fluid Levels Signal Transduction Regulation Of Cell Migration Locomotion Platelet Activation Chemotaxis Actin Cytoskeleton Organization Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Immune Response Actin Filament-based Process Bone Resorption Neurotrophin Signaling Pathway Signaling Regulation Of Locomotion Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Component Movement Cell Communication Cell Proliferation B Cell Receptor Signaling Pathway	Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Response To Stress Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell-cell Adhesion JNK Cascade Regulation Of Signal Transduction Phosphorylation Intracellular Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Toll-like Receptor Signaling Pathway Regulation Of Signaling Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Immune Response Immune System Process Pattern Recognition Receptor Signaling Pathway Defense Response Innate Immune Response-activating Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Activation Of Innate Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Activation Positive Regulation Of Innate Immune Response Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Intracellular Signal Transduction
Tagcloud ?		aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenic splenomegaly srpk2	7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls splenic tnfaip3 tnfr traf3
Tagcloud (Difference) ?		aging ahr aryl committed competitive creb1 division exhaustion gata gfi h2a hematological hes1 hsc hscs hydrocarbon hyperproliferation implicate ink4a ko myelogenous pdp1 premature renewal repopulation serial splenomegaly srpk2	7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls tnfaip3 tnfr traf3
Tagcloud (Intersection) ?		splenic