BAG3 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		BAG3	TINF2
Description		BAG cochaperone 3	TERF1 interacting nuclear factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aggresome Z Disc Ciliary Basal Body Protein Folding Chaperone Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Protein-folding Chaperone Binding Protein Carrier Chaperone	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Autophagosome Assembly Protein Folding Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Striated Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Transport Along Microtubule Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Regulation of HSF1-mediated heat shock response	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 27841878) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 32605384 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Parkinson's disease ( 28892059 27182965 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		76 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 ENTREP1 EYA2 FAM168B FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NEDD8 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UBC UNKL VPS37B WBP2 WNK1	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		9531	26277
HPRD ID		04860	16056
Ensembl ID		ENSG00000151929	ENSG00000092330
Uniprot IDs		O95817	B4DFJ1 Q9BSI4
PDB IDs			3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein Refolding Telomere Assembly Regulation Of Protein Stability Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Signal Transduction Protein Folding Chaperone Complex Negative Regulation Of Signaling Negative Regulation Of Cell Communication Identical Protein Binding Telomere Capping Regulation Of Protein Ubiquitination Response To Unfolded Protein Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Primary Metabolic Process Cytoplasm Nucleus Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Protein Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Intracellular Signal Transduction Protein Folding Chaperone Unfolded Protein Binding WW Domain Binding Convergent Extension Involved In Organogenesis C3HC4-type RING Finger Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Pancreatic Juice Secretion Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Convergent Extension Involved In Gastrulation ATP-dependent Protein Disaggregase Activity Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Folding Negative Regulation Of DNA Biosynthetic Process Regulation Of Apoptotic Signaling Pathway	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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