BAG3 and TMEM174

Number of citations of the paper that reports this interaction (PubMedID 23824909)
75

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BAG3	TMEM174
Description		BAG cochaperone 3	transmembrane protein 174
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aggresome Z Disc Ciliary Basal Body Protein Folding Chaperone Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Protein-folding Chaperone Binding Protein Carrier Chaperone	Protein Binding
	Biological Process	Autophagosome Assembly Protein Folding Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Striated Muscle Cell Apoptotic Process Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Transport Along Microtubule Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy	Phosphate Ion Homeostasis
Pathways		Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 27841878) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 32605384 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 32382064 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Parkinson's disease ( 28892059 27182965 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Blood urea nitrogen levels ( 29403010) Eyebrow thickness ( 26926045) Hemoglobin levels ( 33491795) Monobrow ( 27182965) Monobrow thickness ( 26926045) Renal function-related traits (BUN) ( 22797727)
Interacting Genes		76 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 ENTREP1 EYA2 FAM168B FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NEDD8 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UBC UNKL VPS37B WBP2 WNK1	11 interacting genes: BAG3 CACNB2 CMTM7 CYSRT1 EMD KRT31 KRT34 MAL PLLP SEC22A SGTA
Entrez ID		9531	134288
HPRD ID		04860	14432
Ensembl ID		ENSG00000151929	ENSG00000164325
Uniprot IDs		O95817	Q8WUU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein Refolding Telomere Assembly Regulation Of Protein Stability Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Signal Transduction Protein Folding Chaperone Complex Negative Regulation Of Signaling Negative Regulation Of Cell Communication Identical Protein Binding Telomere Capping Regulation Of Protein Ubiquitination Response To Unfolded Protein Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Neural Plate Elongation Regulation Of Primary Metabolic Process Cytoplasm Nucleus Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Protein Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Intracellular Signal Transduction Protein Folding Chaperone Unfolded Protein Binding WW Domain Binding Convergent Extension Involved In Organogenesis C3HC4-type RING Finger Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Pancreatic Juice Secretion Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Component Organization Convergent Extension Involved In Gastrulation ATP-dependent Protein Disaggregase Activity Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Protein Folding Negative Regulation Of DNA Biosynthetic Process Regulation Of Apoptotic Signaling Pathway	Structural Constituent Of Myelin Sheath Positive Regulation Of Protein Export From Nucleus Epidermis Development Regulation Of Protein Export From Nucleus Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Cellular Localization Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential TMEM240-body Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Protein Transport Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Insertion Into Plasma Membrane Myelination Axon Ensheathment Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane TRC Complex Regulation Of Transcytosis B-1a B Cell Differentiation Regulation Of Nucleocytoplasmic Transport Protein Localization To Paranode Region Of Axon BAT3 Complex Binding Compact Myelin B-1 B Cell Differentiation Membrane Depolarization During AV Node Cell Action Potential Supramolecular Fiber Organization Peptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Aggrephagy Positive Regulation Of Intracellular Transport Localization Within Membrane Photoreceptor Ribbon Synapse Regulation Of Intracellular Protein Transport Developmental Process Intermediate Filament Membrane Raft Distribution Negative Regulation Of ERAD Pathway Chaperone-mediated Autophagy Negative Regulation Of Protein Targeting To Mitochondrion Aggresome Assembly Cortical Endoplasmic Reticulum Membrane Raft Localization Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
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