CCR4 and CCL17

Number of citations of the paper that reports this interaction (PMID 9169480)
51

Data Source:
HPRD (in vitro, in vivo)

		CCR4	CCL17
Gene Name		chemokine (C-C motif) receptor 4	chemokine (C-C motif) ligand 17
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity C-C Chemokine Receptor Activity	Receptor Binding Chemokine Activity CCR4 Chemokine Receptor Binding
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Response To Antibiotic Positive Regulation Of Positive Chemotaxis Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organismal Development Negative Regulation Of Myoblast Differentiation Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Celiac disease ( 20190752)
Protein-Protein Interactions		6 interactors: ADRBK1 ADRBK2 CCL17 CCL22 CCL3 CCL5	4 interactors: ACKR1 CCR4 CCR8 VCAM1
Entrez ID		1233	6361
HPRD ID		05324	03309
Ensembl ID			ENSG00000102970
Uniprot IDs		A0N0Q1 P51679	Q92583
PDB IDs			1NR2 1NR4
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Inflammatory Response Eosinophil Chemotaxis Eosinophil Migration Negative Regulation By Host Of Viral Transcription Immune Response Defense Response Monocyte Chemotaxis Chemotaxis Macrophage Chemotaxis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Viral Transcription Positive Chemotaxis Cell Migration Regulation Of Lymphocyte Migration Interaction With Symbiont Cell Motility Cell-cell Signaling Immune System Process Lipopolysaccharide-mediated Signaling Pathway Protein Kinase B Signaling Receptor Internalization Cellular Response To Interleukin-1 Granulocyte Chemotaxis Termination Of G-protein Coupled Receptor Signaling Pathway Locomotion Termination Of Signal Transduction Positive Regulation Of Leukocyte Chemotaxis Signal Transduction Regulation Of Viral Transcription Protein Phosphorylation Negative Regulation Of Viral Process Positive Regulation Of Phospholipase Activity Receptor Metabolic Process Signaling Vesicle-mediated Transport Response To Interleukin-1 Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Leukocyte Migration Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transport Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Tumor Necrosis Factor Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance Cellular Chemical Homeostasis Chemotaxis Cellular Homeostasis Response To Organic Substance Chemical Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process, No-go Decay Locomotion Immune Response Defense Response Homeostatic Process Membrane To Membrane Docking Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Cytoplasmic MRNA Processing Body Assembly Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Tolerance Induction Chorio-allantoic Fusion Cytoplasmic MRNA Processing Body Assembly Cellular Metal Ion Homeostasis Response To External Stimulus Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Leukocyte Tethering Or Rolling Chronic Inflammatory Response Response To Extracellular Stimulus Metal Ion Homeostasis Response To Bacterium Signal Transduction Immune System Process Signaling Ion Homeostasis Cell Communication Labyrinthine Layer Morphogenesis Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Organelle Assembly
Tagcloud ?		allergic ccr1 ccr3 ccr5 chemokine chemokines coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2 th2s upregulate	addresses adoptive airway antiviral attributable bronchiolitis challenge challenged eosinophil eosinophilia eosinophilic eosinophils eotaxin fi formalin immunized inactivated inadequately lungs partly pulmonary recovered rsv syncytial tarc th2 titers vaccination wheezing
Tagcloud (Difference) ?		allergic ccr1 ccr3 ccr5 chemokine chemokines coreceptors cxc cxcr1 cxcr3 dictate helper homing ige immunodeficiency lesser leukocyte migrate polypeptide precise preferentially prominent superfamily th1 th1s th2s upregulate	addresses adoptive airway antiviral attributable bronchiolitis challenge challenged eosinophil eosinophilia eosinophilic eosinophils eotaxin fi formalin immunized inactivated inadequately lungs partly pulmonary recovered rsv syncytial tarc titers vaccination wheezing
Tagcloud (Intersection) ?		th2