CCR4 and CNTNAP1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR4	CNTNAP1
Description		C-C motif chemokine receptor 4	contactin associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Membrane Paranodal Junction Paranode Region Of Axon Anchoring Junction Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding SH3 Domain Binding Signaling Receptor Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration	Protein Localization To Paranode Region Of Axon Mitochondrion Organization Cytoskeleton Organization Cell Adhesion Signal Transduction Axonogenesis Central Nervous System Development Neuronal Action Potential Propagation Central Nervous System Myelination Myelination In Peripheral Nervous System Paranodal Junction Assembly Neuron Projection Development Myelination Neuron Projection Morphogenesis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuromuscular Process Protein Localization To Juxtaparanode Region Of Axon Regulation Of Synapse Maturation Postsynaptic Density Organization Neuromuscular Junction Development, Skeletal Muscle Fiber Paranodal Junction Maintenance
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Neurofascin interactions
Drugs		Mogamulizumab FLX475
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Breast cancer ( 29059683) Major depressive disorder ( 27777418) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	9 interacting genes: CCR4 FYN LCOR NFASC PTPRB RBM11 RHOA RTN4 SRC
Entrez ID		1233	8506
HPRD ID		05324	03825
Ensembl ID		ENSG00000183813	ENSG00000108797
Uniprot IDs		A0N0Q1 P51679	P78357
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response	Cell Migration Cell Motility Positive Regulation Of Podosome Assembly Phospholipase Activator Activity Regulation Of Podosome Assembly Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Neuron Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Phospholipase Binding Cellular Response To Lectin Ephrin Receptor Binding Glial Cell Migration Cerebral Cortex Cell Migration Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Junction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxidative Stress Fc-gamma Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Telencephalon Cell Migration Regulation Of Cell Projection Organization Substrate Adhesion-dependent Cell Spreading Forebrain Cell Migration Regulation Of Reactive Oxygen Species Biosynthetic Process T Cell Costimulation Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Junction Assembly Positive Regulation Of T Cell Activation Ephrin Receptor Signaling Pathway Cellular Response To Chemical Stress Peptidyl-tyrosine Phosphorylation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synapse Organization Negative Regulation Of Cell-substrate Adhesion Cell Differentiation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Ficolin-1-rich Granule Membrane Actin Filament Bundle Organization Actin Filament Bundle Assembly
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