CCR4 and DHCR24

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR4	DHCR24
Description		C-C motif chemokine receptor 4	24-dehydrocholesterol reductase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Delta24(24-1) Sterol Reductase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Enzyme Binding Peptide Antigen Binding Delta24-sterol Reductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Ras Protein Signal Transduction Intracellular Protein Localization Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Cell Population Proliferation Response To Hormone Tissue Development Sterol Metabolic Process Sterol Biosynthetic Process Male Genitalia Development Plasminogen Activation Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Amyloid Precursor Protein Catabolic Process Skin Development Membrane Organization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Cholesterol biosynthesis Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs		Mogamulizumab FLX475
Diseases			Desmosterolosis
GWAS		Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Visceral fat, circulating phospholipid PC(16:0/2:0) and white matter microstructure (shared variance) ( 31900429)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	2 interacting genes: CCR4 TP53
Entrez ID		1233	1718
HPRD ID		05324	05916
Ensembl ID		ENSG00000183813	ENSG00000116133
Uniprot IDs		A0N0Q1 P51679	Q15392
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response	Cytokine-mediated Signaling Pathway Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Interneuron Migration Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Regulation Of Thymocyte Apoptotic Process Thymocyte Apoptotic Process Negative Regulation Of ATP-dependent Activity ER Overload Response Mitotic G1 DNA Damage Checkpoint Signaling MDM2/MDM4 Family Protein Binding TFIID-class Transcription Factor Complex Binding Replicative Senescence Positive Regulation Of Programmed Necrotic Cell Death Type II Interferon-mediated Signaling Pathway Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Antibiotic Negative Regulation Of Mitophagy Necroptotic Process General Transcription Initiation Factor Binding Regulation Of Regulatory NcRNA Processing
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