CCR4 and GRK3

Number of citations: 0 (PubMedID 10754297)
Data Source: HPRD (in vivo)

		CCR4	GRK3
Name		C-C motif chemokine receptor 4	G protein-coupled receptor kinase 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane Cell Projection Synapse Presynapse Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration	Desensitization Of G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis
Drugs		Mogamulizumab FLX475	ATP
GWAS		Asthma ( 31959851 ) Celiac disease ( 20190752 22057235 ) Multiple sclerosis ( 24076602 ) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603 ) Psychosis proneness (revised social anhedonia scale) ( 28525603 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: CHEK2
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	11 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1 SNCA
Entrez ID		1233	157
HPRD ID		05324	00183
Ensembl ID		ENSG00000183813	ENSG00000100077
Uniprot IDs		A0N0Q1 P51679	P35626 Q8N433
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response	G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Calcium-mediated Signaling Endosome Cell Surface Receptor Signaling Pathway Cell Chemotaxis Negative Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Inflammatory Response Regulation Of Signal Transduction Chemokine-mediated Signaling Pathway Positive Regulation Of Catabolic Process Response To Stress Plasma Membrane Chemotaxis Dendritic Cell Chemotaxis Intracellular Signal Transduction Symbiont Entry Into Host Cell Locomotion Regulation Of Autophagy Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Dendritic Cell Migration Positive Regulation Of Developmental Process Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Biological Process Involved In Interaction With Host Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Organelle Organization Regulation Of Systemic Arterial Blood Pressure Response To Cytokine Positive Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Identical Protein Binding Angiotensin Type I Receptor Activity