CCR4 and B3GAT3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR4	B3GAT3
Description		C-C motif chemokine receptor 4	beta-1,3-glucuronyltransferase 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Homeostasis Of Number Of Cells Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interneuron Migration	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Catalytic Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Glycosaminoglycan-protein linkage region biosynthesis Defective B3GAT3 causes JDSSDHD
Drugs		Mogamulizumab FLX475	UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 20190752 22057235) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Appendicular lean mass ( 33097823) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	5 interacting genes: CCR2 CCR4 GPR35 HNRNPD SEC22B
Entrez ID		1233	26229
HPRD ID		05324	07564
Ensembl ID		ENSG00000183813	ENSG00000149541
Uniprot IDs		A0N0Q1 P51679	G3V150 O94766 Q5U676
PDB IDs			1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?		Calcium Ion Transport Cell Chemotaxis Chemokine Activity Leukocyte Chemotaxis Leukocyte Migration Eosinophil Migration Eosinophil Chemotaxis Beta-adrenergic Receptor Kinase Activity Granulocyte Chemotaxis Positive Regulation Of Macrophage Migration CCR Chemokine Receptor Binding Metal Ion Transport Membrane Granulocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Desensitization Of G Protein-coupled Receptor Signaling Pathway Membrane Organization Chemotaxis Endoplasmic Reticulum Tubular Network Formation CCR1 Chemokine Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Adaptation Of Signaling Pathway Monoatomic Ion Transport Locomotion Endoplasmic Reticulum Tubular Network Membrane Organization Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide CCR5 Chemokine Receptor Binding Regulation Of Macrophage Migration Monoatomic Cation Transport Myeloid Leukocyte Migration Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phospholipase Activator Activity Thyroid Hormone Transport Endoplasmic Reticulum Membrane Positive Regulation Of Transport Host-mediated Suppression Of Viral Transcription Antimicrobial Humoral Response Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Proces Cadherin Binding Macrophage Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Chemotaxis Calcium Ion Transmembrane Transport Steroid Biosynthetic Process Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Heart Contraction Regulation Of Viral Entry Into Host Cell Positive Regulation Of Neuroinflammatory Response	Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity G Protein-coupled Receptor Activity Cytokine-mediated Signaling Pathway Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Circadian Regulation Of Translation Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Calcium-mediated Signaling Homeostasis Of Number Of Cells CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Cell Chemotaxis Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Response To Rapamycin Cell Dedifferentiation Neutrophil Clearance Regulation Of Biological Quality C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Autophagosome Assembly Inflammatory Response To Wounding Positive Regulation Of Glial Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?