NCR1 and CD247

Number of citations of the paper that reports this interaction (PMID 9625766)
100

Data Source:
HPRD (in vivo)

		NCR1	CD247
Gene Name		natural cytotoxicity triggering receptor 1	CD247 molecule
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane SWI/SNF Complex	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Receptor Signaling Protein Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cellular Defense Response Signal Transduction Natural Killer Cell Activation Intracellular Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity	Viral Process T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 20383147 21779181)
Protein-Protein Interactions		3 interactors: CD247 CD59 FCER1G	38 interactors: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		9437	919
HPRD ID		05167	01729
Ensembl ID		ENSG00000189430	ENSG00000198821
Uniprot IDs		O76036	P20963
PDB IDs		1OLL 1P6F	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Acute Inflammatory Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Type III Hypersensitivity Negative Regulation Of Activation Of Membrane Attack Complex Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Phagocytosis Fc Receptor Signaling Pathway Regulation Of Inflammatory Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Serotonin Secretion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Immune System Process Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Lymphocyte Activation Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Blood Coagulation Hemostasis Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Complement Activation Phagocytosis, Engulfment Positive Regulation Of Mast Cell Activation Regulation Of Body Fluid Levels Wound Healing Regulation Of Cell Adhesion Positive Regulation Of Immune Response Endocytosis	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of Immune Response Cell Activation Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Lymphocyte Activation Homotypic Cell-cell Adhesion Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Hemopoiesis Defense Response Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Immune System Development Leukocyte Differentiation T Cell Receptor Signaling Pathway T Cell Costimulation Immune Response T Cell Differentiation Lymphocyte Differentiation Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation In Thymus Positive Regulation Of Signal Transduction Organ Development Response To Stress Response To Stimulus Signal Transduction Regulation Of Body Fluid Levels Leukocyte Migration Cell Adhesion Positive Regulation Of Gamma-delta T Cell Differentiation
Tagcloud ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncrs nk nkp46 partly proto ral rala ralb recognition recognize regressions remarkable retrovirally termed	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Difference) ?		adoptive antitumor capability chimeric combining effectors engineered fused genetically gtp immunotherapeutic killer meaningful mhc moieties ncrs nk nkp46 partly proto ral rala ralb recognition recognize regressions remarkable retrovirally termed	already annotation annotations autoimmunity b6 cd3 characteristically chip coding elements encode encodes encyclopedia enrich gencode intron manual marks project qrt quantification seq spatially supported t1d tcr throughput utilized wealth
Tagcloud (Intersection) ?