NCR1 and ADAM33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCR1	ADAM33
Description		natural cytotoxicity triggering receptor 1	ADAM metallopeptidase domain 33
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GO Annotations	Cellular Component	Plasma Membrane Membrane SWI/SNF Complex	Membrane
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity	Proteolysis
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Regulation of CDH11 function
Drugs
Diseases			Asthma
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		9437	80332
HPRD ID		05167	06173
Ensembl ID		ENSG00000189430	ENSG00000149451
Uniprot IDs		A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036	A2A2L3 Q9BZ11
PDB IDs		1OLL 1P6F 6IAP	1R54 1R55
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Leukocyte Activation Cell Activation Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding External Side Of Plasma Membrane Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Fc Receptor Signaling Pathway Tertiary Granule Membrane IgE Receptor Activity Acetylcholine Receptor Activator Activity Positive Regulation Of Immune System Process PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Membrane Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Immune System Process Activation Of Immune Response Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet	Membrane Plasma Membrane
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