TP53INP1 and MAP1LC3A

Number of citations of the paper that reports this interaction (PubMedID 22421968)
39

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TP53INP1	MAP1LC3A
Description		tumor protein p53 inducible nuclear protein 1	microtubule associated protein 1 light chain 3 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol PML Body Cytoplasmic Vesicle	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Antioxidant Activity	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Autophagosome Assembly Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell Migration Cellular Response To UV Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Autophagic Cell Death Negative Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Cellular Response To Ethanol Cellular Response To Hydroperoxide Cellular Response To Methyl Methanesulfonate Cellular Oxidant Detoxification Negative Regulation Of Myofibroblast Differentiation	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Regulation of TP53 Activity through Phosphorylation	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Fasting glucose ( 34059833) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular thickness ( 30535121) Platelet distribution width ( 32888494) Serum uric acid levels ( 30993211 29403010) Type 2 diabetes ( 20581827 30297969 30054458 32499647 28869590 24509480 22885922) Urate levels ( 31578528)	Alanine aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Hip circumference adjusted for BMI ( 34021172) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		11 interacting genes: GABARAP GABARAPL1 GABARAPL2 HIPK2 MAP1LC3A MAP1LC3C SEC22A SQSTM1 TP53 UNC119 YPEL3	100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304
Entrez ID		94241	84557
HPRD ID		09367	03144
Ensembl ID		ENSG00000164938	ENSG00000101460
Uniprot IDs		Q96A56	Q9H492
PDB IDs			3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Macroautophagy Autophagosome Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagy Autophagosome Membrane Cellular Response To Starvation Response To Starvation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Vacuole Organization GABA Receptor Binding Response To Nutrient Levels Cellular Response To Stress Protein Transport Organelle Assembly Beta-tubulin Binding Establishment Of Protein Localization Cytoplasmic Vesicle Organelle Organization Autolysosome Intracellular Protein Localization Aggrephagy PML Body Positive Regulation Of Cellular Senescence Microtubule Catabolic Process Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Protein-containing Complex Organization SMAD Protein Signal Transduction Cytoskeleton Response To Stress Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of ATP-dependent Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Component Assembly Organelle Membrane Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Senescence DNA Damage Response, Signal Transduction By P53 Class Mediator	Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity
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