TP53INP1 and GABARAPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TP53INP1	GABARAPL1
Description		tumor protein p53 inducible nuclear protein 1	GABA type A receptor associated protein like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol PML Body Cytoplasmic Vesicle	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Protein Binding Antioxidant Activity	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagosome Assembly Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell Migration Cellular Response To UV Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Autophagic Cell Death Negative Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Cellular Response To Ethanol Cellular Response To Hydroperoxide Cellular Response To Methyl Methanesulfonate Cellular Oxidant Detoxification Negative Regulation Of Myofibroblast Differentiation	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Regulation of TP53 Activity through Phosphorylation	Macroautophagy
Drugs
Diseases
GWAS		Alzheimer's disease ( 31473137) Fasting glucose ( 34059833) Hemoglobin levels ( 32327693) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Macular thickness ( 30535121) Platelet distribution width ( 32888494) Serum uric acid levels ( 30993211 29403010) Type 2 diabetes ( 20581827 30297969 30054458 32499647 28869590 24509480 22885922) Urate levels ( 31578528)
Interacting Genes		11 interacting genes: GABARAP GABARAPL1 GABARAPL2 HIPK2 MAP1LC3A MAP1LC3C SEC22A SQSTM1 TP53 UNC119 YPEL3	87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22
Entrez ID		94241	23710
HPRD ID		09367	07601
Ensembl ID		ENSG00000164938	ENSG00000139112
Uniprot IDs		Q96A56	Q9H0R8
PDB IDs			2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Macroautophagy Autophagosome Autophagosome Maturation Ubiquitin Protein Ligase Binding Autophagy Autophagosome Membrane Cellular Response To Starvation Response To Starvation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Vacuole Organization GABA Receptor Binding Response To Nutrient Levels Cellular Response To Stress Protein Transport Organelle Assembly Beta-tubulin Binding Establishment Of Protein Localization Cytoplasmic Vesicle Organelle Organization Autolysosome Intracellular Protein Localization Aggrephagy PML Body Positive Regulation Of Cellular Senescence Microtubule Catabolic Process Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Protein-containing Complex Organization SMAD Protein Signal Transduction Cytoskeleton Response To Stress Cellular Response To Oxygen Levels Regulation Of Protein Metabolic Process Regulation Of ATP-dependent Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Component Assembly Organelle Membrane Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Senescence DNA Damage Response, Signal Transduction By P53 Class Mediator	Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process
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