NRXN1 and SYT4

Number of citations of the paper that reports this interaction (PubMedID 8901523)
0

Data Source:
HPRD (in vitro)

		NRXN1	SYT4
Description		neurexin 1	synaptotagmin 4
Image
GO Annotations	Cellular Component	Nucleolus Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Endocytic Vesicle Neuromuscular Junction Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Axonal Growth Cone Synapse Protein Complex Involved In Cell-cell Adhesion Presynapse Trans-synaptic Protein Complex Glutamatergic Synapse GABA-ergic Synapse	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Vesicle Dense Core Granule Membrane Somatodendritic Compartment Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Exocytic Vesicle Astrocyte Projection Glutamatergic Synapse Neuronal Dense Core Vesicle Neuronal Dense Core Vesicle Membrane Microvesicle
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Angiogenesis Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Adult Behavior Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Social Behavior Protein Localization To Synapse Vocal Learning Positive Regulation Of CAMP-mediated Signaling Establishment Of Protein Localization Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Vocalization Behavior Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering NMDA Glutamate Receptor Clustering Gephyrin Clustering Involved In Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Excitatory Postsynaptic Potential	Vesicle Fusion Neurotransmitter Secretion Memory Positive Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Cell Differentiation Regulation Of Vesicle Fusion Negative Regulation Of Catecholamine Secretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Short-term Neuronal Synaptic Plasticity Negative Regulation Of Protein Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Dense Core Granule Cytoskeletal Transport Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Postsynaptic Dense Core Vesicle Exocytosis Negative Regulation Of Secretion By Cell Positive Regulation Of Dendrite Extension Positive Regulation Of Dense Core Granule Exocytosis Negative Regulation Of Retrograde Trans-synaptic Signaling By Neuropeptide Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Recurrent major depressive disorder ( 34099189) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Smoking initiation ( 33082346) Systolic blood pressure ( 30578418 30224653) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Body mass index ( 25673413 28892062) Carotid intima media thickness x smoking interaction ( 32117412) Ceramide levels (C24:0) ( 32489964) Coffee consumption ( 31046077) Metabolite levels ( 23823483) Parkinson's disease ( 28892059 21738487) Physical activity (moderate intensity activity duration) ( 30531941) Physical activity (overall physical activity time) ( 30531941) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Pulse pressure ( 27841878) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 27841878) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		28 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	13 interacting genes: BRWD1 NBR1 NDUFA12 NRXN1 SGTA SGTB STX1A STX2 STX3 STX4 SYNCRIP SYT1 TFAP2B
Entrez ID		9378	6860
HPRD ID		11858	02519
Ensembl ID		ENSG00000179915	ENSG00000132872
Uniprot IDs		A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 H0Y568 H7BYC7 P58400 Q9ULB1	Q9H2B2
PDB IDs		3B3Q 5Z8Y 6NID	1UGK
Enriched GO Terms of Interacting Partners?		Exocytic Vesicle Calcium-dependent Activation Of Synaptic Vesicle Fusion Calcium-dependent Phospholipid Binding Calcium Ion Sensor Activity Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Calcium Ion-dependent Exocytosis Neurexin Family Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Dense Core Granule Regulation Of Vesicle Fusion SNARE Binding Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Plasma Membrane Regulation Of Vesicle-mediated Transport Phosphatidylinositol-4,5-bisphosphate Binding Synapse Regulation Of Neurotransmitter Secretion Positive Regulation Of Transport Positive Regulation Of Exocytosis Secretion By Cell Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Secretion Positive Regulation Of Cellular Component Organization Postsynaptic Membrane Assembly Excitatory Synapse Neuron To Neuron Synapse Clathrin Binding Cellular Localization Postsynaptic Membrane Organization Presynaptic Membrane Assembly Cell-cell Signaling Positive Regulation Of Secretion By Cell Presynaptic Membrane Organization Regulation Of Transport Signaling Cytoplasmic Vesicle Positive Regulation Of Secretion Cell Communication Exocytosis	SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Neurotransmitter Transport Organelle Membrane Fusion SNAP Receptor Activity SNARE Complex Organelle Fusion Positive Regulation Of Synaptic Transmission Membrane Fusion Secretion By Cell Exocytosis Calcium-dependent Protein Binding Organelle Localization TRC Complex Secretion Vesicle Organization Membrane Organization Positive Regulation Of Regulated Secretory Pathway Cornified Envelope Assembly Membrane Assembly Establishment Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Cell Periphery Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endomembrane System Positive Regulation Of Catecholamine Secretion SNARE Complex Assembly Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Glutamatergic Synapse Vesicle-mediated Transport In Synapse Cellular Localization Specific Granule Schaffer Collateral - CA1 Synapse Secretory Granule Positive Regulation Of Calcium Ion-dependent Exocytosis Vacuole Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface Neuron Projection Positive Regulation Of Neurotransmitter Secretion Regulation Of Regulated Secretory Pathway Membrane Presynaptic Membrane Protein Heterooligomerization Regulation Of Protein Localization To Cell Periphery
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