NRXN1 and SIPA1L1

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NRXN1	SIPA1L1
Gene Name		neurexin 1	signal-induced proliferation-associated 1 like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone	Cellular_component Cytoplasm Cytoskeleton Postsynaptic Density Cell Junction Dendritic Spine Postsynaptic Membrane
	Molecular Function	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Molecular_function GTPase Activator Activity Ephrin Receptor Binding
	Biological Process	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior	Biological_process Actin Cytoskeleton Reorganization Regulation Of Rap GTPase Activity Activation Of Rap GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis
Pathways		Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)	Obesity-related traits ( 23251661) Ventricular conduction ( 21076409)
Protein-Protein Interactions		28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	3 interactors: CEBPE DLG4 NRXN1
Entrez ID		9378	26037
HPRD ID		11858	11559
Ensembl ID		ENSG00000179915	ENSG00000197555
Uniprot IDs		A4FVB9 A7E294 P58400 Q49A31 Q9ULB1	F5GYF8 J3KP19 O43166
PDB IDs		3B3Q
Enriched GO Terms of Interacting Partners?		Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization	Regulation Of Grooming Behavior Receptor Localization To Synapse Vocalization Behavior Protein Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Postsynaptic Membrane Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Social Behavior Positive Regulation Of Membrane Potential Receptor Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Synapse Assembly Neuromuscular Process Controlling Balance Positive Regulation Of Synaptic Transmission Membrane Depolarization Regulation Of Receptor Activity Neuromuscular Process Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Synapse Organization Regulation Of Behavior Vesicle Localization Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Gephyrin Clustering Synaptic Vesicle Clustering Learning Or Memory Regulation Of Membrane Potential Cognition Neuronal Signal Transduction Response To External Stimulus Regulation Of Synaptic Transmission N-methyl-D-aspartate Receptor Clustering Vocal Learning Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Synapse Maturation Axon Guidance Organelle Localization Regulation Of Ion Transmembrane Transport Negative Regulation Of Receptor Internalization Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?