NRXN1 and SDCBP2

Number of citations of the paper that reports this interaction (PMID 11152476)
24

Data Source:
HPRD (two hybrid)

		NRXN1	SDCBP2
Gene Name		neurexin 1	syndecan binding protein (syntenin) 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone	Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Protein C-terminus Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior	Nervous System Development Intracellular Signal Transduction Intracellular Transport
Pathways		Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)
Protein-Protein Interactions		28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	41 interactors: ADAP1 ARF4 BEND7 C11orf57 C1orf35 CT45A3 CT45A5 CTH DPPA2 EIF1AD FAM133A FAM13C FAM9B FBXO28 GABRA3 LGALS14 LGALS2 LYAR NFASC NPM2 NRXN1 NUF2 PAFAH1B3 PRPF38A PRPF40A PRR13 PTMS RNPS1 SDCBP SEC23A SREK1IP1 TDO2 THAP6 TIFA TM4SF1 TNP1 YTHDC1 ZCCHC10 ZCCHC17 ZNF581 ZRSR2
Entrez ID		9378	27111
HPRD ID		11858	18032
Ensembl ID		ENSG00000179915	ENSG00000125775
Uniprot IDs		A4FVB9 A7E294 P58400 Q49A31 Q9ULB1	Q9H190
PDB IDs		3B3Q
Enriched GO Terms of Interacting Partners?		Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Cellular Component Assembly Protein Complex Assembly Involved In Synapse Maturation Fertilization, Exchange Of Chromosomal Proteins Gamma-aminobutyric Acid Receptor Clustering Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cellular Nitrogen Compound Metabolic Process Locomotion MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Assembly Male Pronucleus Assembly Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Protein-pyridoxal-5-phosphate Linkage Transsulfuration Tryptophan Catabolic Process To Acetyl-CoA Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gephyrin Clustering Synaptic Vesicle Clustering Hydrogen Sulfide Biosynthetic Process
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?