NRXN1 and APBA2

Number of citations of the paper that reports this interaction (PMID 11036064)
49

Data Source:
HPRD (in vitro)

		NRXN1	APBA2
Gene Name		neurexin 1	amyloid beta (A4) precursor protein-binding, family A, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Endocytic Vesicle Presynaptic Membrane Axonal Growth Cone	Plasma Membrane
	Molecular Function	Receptor Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Beta-amyloid Binding Protein Binding
	Biological Process	Angiogenesis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Extracellular Matrix Organization Adult Behavior Social Behavior Protein Localization To Synapse Vocal Learning Establishment Of Protein Localization Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vocalization Behavior Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Protein Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering N-methyl-D-aspartate Receptor Clustering Gephyrin Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior	In Utero Embryonic Development Synaptic Transmission Nervous System Development Locomotory Behavior Regulation Of Gene Expression Protein Transport Multicellular Organism Growth
Pathways		Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS		Longevity ( 20834067) Metabolite levels (HVA/MHPG ratio) ( 23319000) Personality dimensions ( 20691247) Temperament ( 22832960)	Temperament ( 22832960)
Protein-Protein Interactions		28 interactors: APBA1 APBA2 ATP13A2 CASK MACF1 MLLT4 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3	11 interactors: APP CLSTN1 CLSTN3 LRP1 LRP2 LRP8 MAPK6 NECAB3 NRXN1 RELA STXBP1
Entrez ID		9378	321
HPRD ID		11858	04090
Ensembl ID		ENSG00000179915	ENSG00000034053
Uniprot IDs		A4FVB9 A7E294 P58400 Q49A31 Q9ULB1	Q59G28 Q99767
PDB IDs		3B3Q
Enriched GO Terms of Interacting Partners?		Secretion Exocytosis Secretion By Cell Transport Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynaptic Membrane Organization Regulation Of Calcium Ion-dependent Exocytosis Cell-cell Signaling Regulation Of Respiratory Gaseous Exchange By Neurological System Process Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Exocytosis Regulation Of Exocytosis Regulation Of Synaptic Transmission, Glutamatergic Neuron Cell-cell Adhesion Regulation Of Respiratory System Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Respiratory Gaseous Exchange Synaptic Transmission Membrane Biogenesis Terminal Button Organization Postsynaptic Membrane Organization Regulation Of Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Synapse Assembly Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Transport Positive Regulation Of Membrane Potential Regulation Of Synaptic Transmission Regulation Of Dendritic Spine Development Positive Regulation Of Secretion Regulation Of Synapse Assembly Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Postsynaptic Density Protein 95 Clustering Regulation Of Excitatory Postsynaptic Membrane Potential Cellular Protein Localization Regulation Of Postsynaptic Membrane Potential Synapse Assembly Protein Transport Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Establishment Of Protein Localization Regulation Of Synapse Organization Protein Localization	Response To Light Stimulus Response To Radiation Response To Abiotic Stimulus Synapse Assembly Phototransduction, Visible Light Retinoid Metabolic Process Endocytosis Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Nervous System Development Isoprenoid Metabolic Process Synapse Organization Secretion By Cell Detection Of Abiotic Stimulus Response To External Stimulus Signaling System Development Cell Communication Cell Adhesion Secretion Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Steroid Metabolic Process Multicellular Organismal Development Vesicle-mediated Transport Anatomical Structure Development Brain Development Anatomical Structure Morphogenesis Regulation Of Synaptic Transmission Head Development Regulation Of Protein Tyrosine Kinase Activity Generation Of Neurons Alcohol Metabolic Process Platelet Degranulation Ammon Gyrus Development Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Beta-amyloid Clearance Acetaldehyde Metabolic Process Receptor-mediated Endocytosis Neurogenesis Neuromuscular Process Controlling Balance Developmental Process Central Nervous System Development Regulation Of Synapse Structure Or Activity Blood Coagulation Hemostasis
Tagcloud ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	a4 ageing apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled rnf219 sv2a transcriptome transcriptomic unaffected
Tagcloud (Difference) ?		a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss	a4 ageing apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled rnf219 sv2a transcriptome transcriptomic unaffected
Tagcloud (Intersection) ?