NF2 and EZR

Number of citations of the paper that reports this interaction (PubMedID 17891137)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		NF2	EZR
Description		NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	ezrin
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Cell Projection Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cytoplasm Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Microvillus Brush Border Adherens Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Actin Binding Integrin Binding Protein Binding Cytoskeletal Protein Binding	RNA Binding Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding
	Biological Process	MAPK Cascade Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Ectoderm Development Brain Development Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Negative Regulation Of Schwann Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Stability Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Receptor Internalization Regulation Of Microvillus Length Negative Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Filopodium Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Postsynaptic Actin Cytoskeleton Organization Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Malignant pleural mesothelioma
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168) Refractive error ( 32231278)
Interacting Genes		72 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DSCAM EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC NHERF1 PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 RSPH1 SCHIP1 SDCBP SGSM3 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1	57 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CEBPA CFTR CLIC5 CTNNB1 DLG1 EGFR ERBB3 FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 NHERF1 NHERF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 RSPH1 S100P SCYL3 SDC2 SELL SELP SLC26A4-AS1 SPN SUMO2 TBC1D10A TMEM8B TSC1 USP1 VCAM1 VPS11 WFDC1 WWOX
Entrez ID		4771	7430
HPRD ID		06980	00475
Ensembl ID		ENSG00000186575	ENSG00000092820
Uniprot IDs		A0A5K1VW66 P35240	P15311
PDB IDs		1H4R 3U8Z 4ZRI 4ZRJ 6CDS 7LWH	1NI2 4RM8 4RM9 4RMA 7T1K 7T1L
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cell Population Proliferation Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Developmental Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Cellular Developmental Process Regulation Of Protein Localization Regulation Of Protein Modification Process Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Protein Serine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle	Plasma Membrane Cell Adhesion Cell-cell Adhesion Focal Adhesion Leukocyte Cell-cell Adhesion Cell Migration Cell Motility Microvillus Regulation Of Intracellular Signal Transduction Lamellipodium Extracellular Exosome Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Tethering Or Rolling Regulation Of Multicellular Organismal Process Response To Growth Factor Positive Regulation Of Transport Regulation Of Cell-cell Adhesion Filopodium Regulation Of Developmental Process Regulation Of Cell Migration Cell Projection Regulation Of Signal Transduction Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Membrane Docking Cell Surface Cellular Developmental Process Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Regulation Of Programmed Cell Death Apical Plasma Membrane Integrin Binding Developmental Process Regulation Of Locomotion Cell-substrate Adhesion T Cell Activation Cell-matrix Adhesion Ruffle
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