NF2 and EIF3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NF2	EIF3B
Description		NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	eukaryotic translation initiation factor 3 subunit B
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Cell Projection Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Actin Binding Integrin Binding Protein Binding Cytoskeletal Protein Binding	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Ectoderm Development Brain Development Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Negative Regulation Of Schwann Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Stability Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation IRES-dependent Viral Translational Initiation Viral Translational Termination-reinitiation
Pathways		Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Malignant pleural mesothelioma
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		72 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DSCAM EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC NHERF1 PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 RSPH1 SCHIP1 SDCBP SGSM3 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1	18 interacting genes: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 GPRASP3 IL2RB LMO2 NDUFAB1 NF2 NREP PAIP1 PBX4 RPS6KB1 TBC1D23 TNNI1 UPF1
Entrez ID		4771	8662
HPRD ID		06980	06795
Ensembl ID		ENSG00000186575	ENSG00000106263
Uniprot IDs		A0A5K1VW66 P35240	P55884
PDB IDs		1H4R 3U8Z 4ZRI 4ZRJ 6CDS 7LWH	2KRB 2NLW 5K1H 6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cell Population Proliferation Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Developmental Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Cellular Developmental Process Regulation Of Protein Localization Regulation Of Protein Modification Process Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Protein Serine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle	Cytoplasmic Translational Initiation Translational Initiation Translation Initiation Factor Activity Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translation Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-RNA Complex Assembly XY Body Regulation Of Translational Initiation Cytosol RNA Binding Positive Regulation Of Translation Behavioral Fear Response Behavioral Defense Response Fear Response Regulation Of Translation Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Acyl Carrier Activity
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