NF2 and TTYH2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NF2	TTYH2
Description		NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	tweety family member 2
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleolus Cytoplasm Early Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Cell Projection Neuron Projection Cell Body Apical Part Of Cell Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Chloride Channel Complex
	Molecular Function	Actin Binding Integrin Binding Protein Binding Cytoskeletal Protein Binding	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Calcium Ion Binding Protein Binding Metal Ion Binding Volume-sensitive Chloride Channel Activity
	Biological Process	MAPK Cascade Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Ectoderm Development Brain Development Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Negative Regulation Of Schwann Cell Proliferation Schwann Cell Proliferation Regulation Of Gliogenesis Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Stability Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurogenesis Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Lens Fiber Cell Differentiation Regulation Of Stem Cell Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Early Endosome To Late Endosome Transport	Monoatomic Ion Transport Chloride Transport L-glutamate Transmembrane Transport Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Stimuli-sensing channels
Drugs
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Malignant pleural mesothelioma
GWAS		Carotid atherosclerosis in HIV infection ( 20009918)	Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		72 interacting genes: AGAP2 AKT1 AMOTL2 ARAF ARNT AURKA BDKRB1 BECN1 BYSL CBLC CCNB1IP1 CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2B CDKN2C CTNNB1 DACH1 DCAF1 DSCAM EGFR EIF3B EMD EPHA2 ERBB2 EZR FGFR4 FZR1 GLIS2 GRM1 HGF HGS HIF1A IGF1R ITGB1 KAT2A KDELR2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MDM4 MED28 MET MYBPC2 MYC NHERF1 PAK1 PDGFRA PRKCA PXN PYGO2 RAF1 RALGDS RASSF1 RSPH1 SCHIP1 SDCBP SGSM3 SOX3 SOX4 SPTBN1 STK11 TARBP2 TERT TP53 TSC1 TTYH2 TXLNB XPO1	15 interacting genes: CCND2 CDKN2B COPB1 ERBB2 FGFR4 GPR37 GRM1 IGF1R IKBKG KAT2A KDELR2 NEDD4 NF2 PDGFRA TRARG1
Entrez ID		4771	94015
HPRD ID		06980	16394
Ensembl ID		ENSG00000186575	ENSG00000141540
Uniprot IDs		A0A5K1VW66 P35240	B4DKD1 Q9BSA4
PDB IDs		1H4R 3U8Z 4ZRI 4ZRJ 6CDS 7LWH	7P54 7P5M
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Kinase Activity Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Signal Transduction Animal Organ Development Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Regulation Of Fibroblast Proliferation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cell Population Proliferation Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Developmental Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Developmental Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Cellular Developmental Process Regulation Of Protein Localization Regulation Of Protein Modification Process Negative Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Protein Serine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle	Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Tyrosine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction COPI-coated Vesicle Membrane Transport Vesicle Ubiquitin Ligase Complex Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Regulation Of Cell Population Proliferation Phosphorylation Long-term Memory Neuromuscular Junction Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Protein Kinase Activity Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity G Protein-coupled Receptor Homodimeric Complex G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Formation Of Structure Involved In A Symbiotic Process Platelet-derived Growth Factor Alpha-receptor Activity Plasma Membrane Protein Modification Process ERBB3:ERBB2 Complex Kinase Activity Histone H3K9 Acetyltransferase Activity Prosaposin Receptor Activity Dendriole Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Dimeric Complex Channel Inhibitor Activity Odontogenesis Of Dentin-containing Tooth Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
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