LHCGR and CGB3

Number of citations: 0 (PubMedID 2254302)
Data Source: HPRD (in vivo)

		LHCGR	CGB3
Name		luteinizing hormone/choriogonadotropin receptor	chorionic gonadotropin subunit beta 3
Structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Centriolar Satellite	Extracellular Region Extracellular Space Cytoplasm Pituitary Gonadotropin Complex
	Molecular Function	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding	Signaling Receptor Binding Hormone Activity Protein Binding
	Biological Process	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process	Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Gamete Generation Hormone-mediated Signaling Pathway
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	Glycoprotein hormones TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs		Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)	None
Diseases		Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	None
GWAS		A body shape index ( 34021172 ) Body mass index ( 28892062 ) Hip circumference adjusted for BMI ( 34021172 ) Laterality in neovascular age-related macular degeneration ( 28775256 ) Polycystic ovary syndrome ( 21151128 22885925 ) Sex hormone-binding globulin levels ( 22829776 ) Triglyceride levels ( 32154731 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Interacting Genes		11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR	7 interacting genes: APP CFTR CGA FSHB LHCGR NLGN3 SMCP
Entrez ID		3973	1082
HPRD ID		01073	00343
Ensembl ID		ENSG00000138039	ENSG00000104827
Uniprot IDs		P22888	A0A0F7RQP8 P0DN86
PDB IDs		7FIG 7FIH 7FII 7FIJ	1HCN 1HRP 1QFW 7FIG 7FIH 7FII
GO Terms Enriched among Interactors		Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex Ovulation Cycle Process Follicle-stimulating Hormone Signaling Pathway Reproductive Process Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process Regulation Of Hormone Levels Regulation Of Lipid Biosynthetic Process Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Biological Quality Positive Regulation Of Steroid Biosynthetic Process Rhythmic Process Positive Regulation Of Steroid Metabolic Process G Protein-coupled Receptor Signaling Pathway Ovarian Follicle Development Modulation Of Excitatory Postsynaptic Potential Cognition Cellular Response To CAMP Developmental Process Involved In Reproduction Regulation Of Lipid Metabolic Process Amyloid-beta Complex Developmental Growth Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Steroid Biosynthetic Process Regulation Of Membrane Potential Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Developmental Process Golgi Lumen Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway