LHCGR and CGA

Number of citations of the paper that reports this interaction (PMID 10342833)
2

Data Source:
HPRD (in vitro)

		LHCGR	CGA
Gene Name		luteinizing hormone/choriogonadotropin receptor	glycoprotein hormones, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region
	Molecular Function	Luteinizing Hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding	Hormone Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Male Gonad Development Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Cognition Cellular Response To Gonadotropin Stimulus	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Peptide Hormone Processing Positive Regulation Of Cell Migration Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Amine-derived hormones Metabolism of lipids and lipoproteins Mineralocorticoid biosynthesis G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Androgen biosynthesis Metabolism of amino acids and derivatives Metabolism of steroid hormones and vitamin D Peptide hormone metabolism GPCR downstream signaling Glycoprotein hormones Thyroxine biosynthesis Peptide hormone biosynthesis
Drugs		Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin
Diseases
GWAS		Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		11 interactors: ARRB2 CANX CGA CGB CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR	8 interactors: CGB CGB5 FSHB LHB LHCGR PTN PTPN12 TSHB
Entrez ID		3973	1081
HPRD ID		01073	00342
Ensembl ID		ENSG00000138039	ENSG00000135346
Uniprot IDs		P22888	P01215 Q6I9S8
PDB IDs		1LUT 1XUL	1DZ7 1E9J 1FL7 1HCN 1HD4 1HRP 1QFW 1XUL 1XWD 4AY9
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Processing Hormone Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Levels G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Metabolic Process Signal Transduction Platelet Activation Dopamine Receptor Signaling Pathway Secretion Positive Regulation Of Signal Transduction Protein Processing Cell Activation Cellular Amide Metabolic Process Hormone Biosynthetic Process Cellular Response To Stimulus Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Transmission Acid Secretion Positive Regulation Of Intracellular Signal Transduction Regulation Of Cyclase Activity Renal Phosphate Ion Absorption Post-embryonic Body Morphogenesis Regulation Of CAMP Biosynthetic Process Blood Coagulation Hemostasis Renal System Process Negative Regulation Of Sodium:proton Antiporter Activity Thyroid-stimulating Hormone Signaling Pathway Glutathione Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Multicellular Organism Growth Regulation Of CAMP Metabolic Process Protein Localization Adult Locomotory Behavior Cell Surface Receptor Signaling Pathway Secretion By Cell Protein Secretion Regulation Of Protein Kinase B Signaling Response To Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Reproductive Process	Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Female Gamete Generation Progesterone Biosynthetic Process Male Gonad Development Single Organism Reproductive Process Progesterone Metabolic Process C21-steroid Hormone Biosynthetic Process Reproductive Process Male Sex Differentiation C21-steroid Hormone Metabolic Process Gonad Development Development Of Primary Sexual Characteristics Sex Differentiation Cell-cell Signaling Hormone Biosynthetic Process Signal Transduction Signaling Cell Communication Cellular Ketone Metabolic Process Reproductive Structure Development Reproductive System Development Steroid Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Stimulus Luteinizing Hormone Signaling Pathway Gamete Generation Developmental Process Involved In Reproduction Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Follicle-stimulating Hormone Signaling Pathway Sertoli Cell Proliferation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein Metabolic Process Steroid Metabolic Process Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Stimulus Positive Regulation Of Inositol Phosphate Biosynthetic Process Reproduction Cognition Positive Regulation Of CAMP-mediated Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Bone Resorption Regulation Of CAMP-mediated Signaling
Tagcloud ?		ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr	aberrations arginine codon documented encode faulty finger fingers gonads hotspot mesothelium mobility mutational nonsense spleen sscp stop strand substituted tga tumours urogenital uterus wilms wt wt1 wts zf3 zinc
Tagcloud (Difference) ?		ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fsh fshr fshrs gonadotrophin linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr	aberrations arginine codon documented encode faulty finger fingers gonads hotspot mesothelium mobility mutational nonsense spleen sscp stop strand substituted tga tumours urogenital uterus wilms wt wt1 wts zf3 zinc
Tagcloud (Intersection) ?