LHCGR and CHST9

Number of citations: 0 (PubMedID 11445554)
Data Source: HPRD (in vitro)

		LHCGR	CHST9
Name		luteinizing hormone/choriogonadotropin receptor	carbohydrate sulfotransferase 9
Structure			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Centriolar Satellite	Golgi Membrane Extracellular Region Golgi Apparatus Membrane
	Molecular Function	G Protein-coupled Receptor Activity Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding	Dermatan 4-sulfotransferase Activity Sulfotransferase Activity Transferase Activity Chondroitin 4-sulfotransferase Activity
	Biological Process	Ovarian Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Cellular Response To Hormone Stimulus Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Response To Gonadotropin Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cognition Uterus Development Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus Seminiferous Tubule Development Regulation Of Steroid Hormone Biosynthetic Process	Sulfur Compound Metabolic Process Carbohydrate Biosynthetic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Hormone Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events	None
Drugs		Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)	None
Diseases		Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	None
GWAS		A body shape index ( 34021172 ) Body mass index ( 28892062 ) Hip circumference adjusted for BMI ( 34021172 ) Laterality in neovascular age-related macular degeneration ( 28775256 ) Polycystic ovary syndrome ( 21151128 22885925 ) Sex hormone-binding globulin levels ( 22829776 ) Triglyceride levels ( 32154731 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Blood protein levels ( 30072576 ) Breast cancer ( 23535729 29059683 ) Bronchopulmonary dysplasia ( 23897914 ) Dental caries ( 23259602 ) Metabolite levels ( 23823483 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482 )
Novel Interactors		None recorded	1 novel interactors: MIB1
Interacting Genes		11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB NHERF1 TSHR	1 interacting genes: LHCGR
Entrez ID		3973	83539
HPRD ID		01073	13058
Ensembl ID		ENSG00000138039	ENSG00000154080
Uniprot IDs		P22888	Q7L1S5
PDB IDs		7FIG 7FIH 7FII 7FIJ	Not available
GO Terms Enriched among Interactors		Pituitary Gonadotropin Complex G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Signaling Regulation Of Biological Quality Cell Communication Hormone Activity Guanyl Nucleotide Binding Renal System Process Secretion By Cell G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Dopamine Receptor Signaling Pathway Signal Transduction Heterotrimeric G-protein Complex Hormone Metabolic Process Regulation Of Hormone Levels Hormone Biosynthetic Process Postsynaptic Signal Transduction Acidic Amino Acid Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Thyrotropin-releasing Hormone Renal Phosphate Ion Absorption Regulation Of ERK1 And ERK2 Cascade Angiotensin Receptor Binding G Protein-coupled Receptor Binding Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Follicle-stimulating Hormone Secretion Follicle-stimulating Hormone Activity Cellular Response To Hormone Stimulus Follicle-stimulating Hormone Complex Mu-type Opioid Receptor Binding Thyroid-stimulating Hormone Receptor Activity Thyroid-stimulating Hormone Signaling Pathway Response To Thyrotropin-releasing Hormone Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Negative Regulation Of Developmental Growth Positive Regulation Of Synaptic Transmission, Dopaminergic Golgi Lumen Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Centriolar Satellite Choriogonadotropin Hormone Binding Choriogonadotropin Hormone Receptor Activity Luteinizing Hormone Receptor Activity Luteinizing Hormone Signaling Pathway Development Of Secondary Male Sexual Characteristics Cellular Response To Luteinizing Hormone Stimulus Regulation Of Inositol Trisphosphate Biosynthetic Process Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Development Of Secondary Sexual Characteristics Response To Luteinizing Hormone Neural Tube Formation Protein-hormone Receptor Activity Positive Regulation Of Inositol Phosphate Biosynthetic Process Male Genitalia Development Regulation Of Steroid Hormone Biosynthetic Process Regulation Of Hormone Biosynthetic Process Seminiferous Tubule Development Reproductive System Development Cellular Response To Gonadotropin Stimulus Uterus Development Female Gonad Development Embryonic Epithelial Tube Formation Response To Gonadotropin Genitalia Development Regulation Of Hormone Metabolic Process G Protein-coupled Peptide Receptor Activity Epithelial Tube Formation Ovulation Cycle Process Ovarian Follicle Development Somitogenesis G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Segmentation Animal Organ Development Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Regulation Of Steroid Biosynthetic Process