KCNJ1 and SLC9A3R2

Number of citations of the paper that reports this interaction (PMID 14604981)
22

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		KCNJ1	SLC9A3R2
Gene Name		potassium channel, inwardly rectifying subfamily J, member 1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Inward Rectifier Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding
	Biological Process	Kidney Development Tissue Homeostasis Potassium Ion Transport Synaptic Transmission Excretion Post-embryonic Development Potassium Ion Import Regulation Of Ion Transmembrane Transport Renal Sodium Ion Absorption Cardiovascular System Development Regulation Of G-protein Activated Inward Rectifier Potassium Channel Activity	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Pathways		Inwardly rectifying K+ channels Potassium transport channels Potassium Channels
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Tolazamide Glyburide Tolbutamide Glycodiazine Agmatine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: GOLGA3 IL16 PRKCD SGK1 SH3RF1 SLC9A3R1 SLC9A3R2 UBC	35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		3758	9351
HPRD ID		08981	05946
Ensembl ID		ENSG00000151704	ENSG00000065054
Uniprot IDs		A8K432 P48048	Q15599
PDB IDs			2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Renal Sodium Ion Transport Renal Absorption Negative Regulation Of Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Transporter Activity Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Intracellular Signal Transduction Renal Phosphate Ion Absorption Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Renal System Process Regulation Of Phosphorylation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Phospholipid Catabolic Process Glutathione Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Interleukin-10 Production Regulation Of Locomotion Negative Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Renal Sodium Ion Absorption Negative Regulation Of Filopodium Assembly Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Protein Kinase Activity Interleukin-12 Production Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Catalytic Activity Response To Fibroblast Growth Factor Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Phosphate Ion Homeostasis Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Sodium:proton Antiporter Activity	Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype
Tagcloud (Difference) ?		2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype
Tagcloud (Intersection) ?