KCNJ1 and SGK1

Number of citations: 0 (PubMedID 12684516)
Data Source: HPRD (in vitro)

		KCNJ1	SGK1
Name		potassium inwardly rectifying channel subfamily J member 1	serum/glucocorticoid regulated kinase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Monoatomic Ion Channel Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Kidney Development Tissue Homeostasis Monoatomic Ion Transport Potassium Ion Transport Post-embryonic Development Gene Expression Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Renal Sodium Ion Absorption Circulatory System Development Potassium Ion Import Across Plasma Membrane	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone
Pathways		Potassium transport channels	PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Ritodrine Tolbutamide Glymidine Yohimbine Agmatine Butamben	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases		Bartter syndrome	None
GWAS		No GWAS studies recorded	Blond vs. brown/black hair color ( 30531825 ) Body mass index (smoking years interaction) ( 23192594 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465 ) Pelvic organ prolapse ( 26545240 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Refractive error ( 32231278 ) Schizophrenia (inflammation and infection response interaction) ( 25781172 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
Novel Interactors		4 novel interactors: APLP2 CTSV EI24 NID2	None recorded
Interacting Genes		6 interacting genes: GOLGA3 NHERF1 NHERF2 PRKCD SGK1 SH3RF1	38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC
Entrez ID		3758	6446
HPRD ID		08981	04264
Ensembl ID		ENSG00000151704	ENSG00000118515
Uniprot IDs		A8K432 P48048	B7Z325 E9PR89 O00141
PDB IDs		Not available	2R5T 3HDM 3HDN 7PUE
GO Terms Enriched among Interactors		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Chloride Channel Regulator Activity Regulation Of Apoptotic Signaling Pathway Response To Aldosterone Positive Regulation Of Apoptotic Signaling Pathway Renal Sodium Ion Transport Protein-membrane Adaptor Activity Response To Mineralocorticoid Positive Regulation Of Transporter Activity Renal Absorption Endomembrane System Phosphatase Binding Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Protein Import Into Nucleus Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cellular Response To UV Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Cellular Response To Light Stimulus Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Beta-catenin Binding Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Renal System Process Extracellular Exosome Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of MAPK Cascade Positive Regulation Of Programmed Cell Death Response To UV Regulation Of Intracellular Protein Transport Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Protein Localization To Nucleus Regulation Of Endodeoxyribonuclease Activity Regulation Of Intracellular Signal Transduction Regulation Of Phospholipid Catabolic Process Cellular Response To Aldosterone	Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus