KCNJ1 and SGK1

Number of citations of the paper that reports this interaction (PMID 12684516)
38

Data Source:
HPRD (in vitro)

		KCNJ1	SGK1
Gene Name		potassium channel, inwardly rectifying subfamily J, member 1	serum/glucocorticoid regulated kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity
	Biological Process	Kidney Development Tissue Homeostasis Potassium Ion Transport Synaptic Transmission Excretion Post-embryonic Development Potassium Ion Import Regulation Of Ion Transmembrane Transport Renal Sodium Ion Absorption Cardiovascular System Development Regulation Of G-protein Activated Inward Rectifier Potassium Channel Activity	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption
Pathways		Inwardly rectifying K+ channels Potassium transport channels Potassium Channels	Ion channel transport Stimuli-sensing channels
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Tolazamide Glyburide Tolbutamide Glycodiazine Agmatine
Diseases
GWAS			Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		8 interactors: GOLGA3 IL16 PRKCD SGK1 SH3RF1 SLC9A3R1 SLC9A3R2 UBC	31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C
Entrez ID		3758	6446
HPRD ID		08981	04264
Ensembl ID		ENSG00000151704	ENSG00000118515
Uniprot IDs		A8K432 P48048	E9PR89 O00141
PDB IDs			2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?		Renal Sodium Ion Transport Renal Absorption Negative Regulation Of Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Transporter Activity Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Intracellular Signal Transduction Renal Phosphate Ion Absorption Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Renal System Process Regulation Of Phosphorylation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Phospholipid Catabolic Process Glutathione Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Interleukin-10 Production Regulation Of Locomotion Negative Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Renal Sodium Ion Absorption Negative Regulation Of Filopodium Assembly Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Protein Kinase Activity Interleukin-12 Production Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Catalytic Activity Response To Fibroblast Growth Factor Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Phosphate Ion Homeostasis Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Sodium:proton Antiporter Activity	Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process
Tagcloud ?		2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Difference) ?		2cl a198t ante antenatal ascending ba2 bartter cdnas cos cotransport currents d108h henle infrequently inwardly kir mg2 p110l potassium reabsorption rectifying romk romk1 salt talh v315g v72e wasting wildtype	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Intersection) ?