LPAR2 and SLC9A3R2

Number of citations of the paper that reports this interaction (PMID 16203867)
43

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LPAR2	SLC9A3R2
Gene Name		lysophosphatidic acid receptor 2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)
Protein-Protein Interactions		6 interactors: ARHGEF11 ARHGEF12 ATXN1 SLC9A3R1 SLC9A3R2 TRIP6	35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		9170	9351
HPRD ID		05487	05946
Ensembl ID		ENSG00000064547	ENSG00000065054
Uniprot IDs		Q9HBW0	Q15599
PDB IDs			2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Renal Sodium Ion Transport Release Of Cytoplasmic Sequestered NF-kappaB Neurotrophin Signaling Pathway Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Rho GTPase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Rho GTPase Activity G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Bile Acid Secretion Regulation Of Rho Protein Signal Transduction Oligopeptide Transport Apoptotic Signaling Pathway Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phosphate Ion Homeostasis Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Assembly Axon Guidance Negative Regulation Of Phosphorylation Cell Communication Regulation Of Apoptotic Process Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple
Tagcloud (Difference) ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple
Tagcloud (Intersection) ?