LPAR2 and ARHGEF12

Number of citations of the paper that reports this interaction (PMID 15755723)
36

Data Source:
HPRD (in vitro, in vivo)

		LPAR2	ARHGEF12
Gene Name		lysophosphatidic acid receptor 2	Rho guanine nucleotide exchange factor (GEF) 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity	G-protein Coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction	G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Semaphorin interactions p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)
Protein-Protein Interactions		6 interactors: ARHGEF11 ARHGEF12 ATXN1 SLC9A3R1 SLC9A3R2 TRIP6	13 interactors: ABCA1 CD44 CUL3 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 RHOA TEC
Entrez ID		9170	23365
HPRD ID		05487	09207
Ensembl ID		ENSG00000064547	ENSG00000196914
Uniprot IDs		Q9HBW0	B4E2K6 E9PMR6 Q9NZN5
PDB IDs			1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Renal Sodium Ion Transport Release Of Cytoplasmic Sequestered NF-kappaB Neurotrophin Signaling Pathway Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Rho GTPase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Rho GTPase Activity G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Bile Acid Secretion Regulation Of Rho Protein Signal Transduction Oligopeptide Transport Apoptotic Signaling Pathway Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phosphate Ion Homeostasis Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Assembly Axon Guidance Negative Regulation Of Phosphorylation Cell Communication Regulation Of Apoptotic Process Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signal Transduction Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Signaling Cell Communication Regulation Of Cell Motility Anatomical Structure Morphogenesis Tissue Morphogenesis Regulation Of Ras Protein Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stimulus Positive Regulation Of Cytokinesis Regulation Of Cell Shape Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Cell Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cytokinesis Rho Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Morphogenesis Of An Epithelium Positive Regulation Of Neuron Projection Development Regulation Of Catalytic Activity Positive Regulation Of Axonogenesis Positive Regulation Of Phospholipase Activity Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Wound Healing Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Cycle Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organismal Development Intracellular Signal Transduction Anatomical Structure Development Response To Wounding Positive Regulation Of Neuron Differentiation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Ossification Involved In Bone Maturation
Tagcloud ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Difference) ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple	11q23 adulthood beginning bronchi catalyzing colocalization embryogenesis exchange gastrulation gdp gtp gtpases guanine homologue incompletely intestine larg melanogaster mll morphogenesis neurite observe originally outgrowth physiologic rho rhoa undetectable vasculature
Tagcloud (Intersection) ?