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LPAR2 and ARHGEF11
Number of citations of the paper that reports this interaction (PMID
15755723
)
36
Data Source:
HPRD
(in vivo, in vitro)
LPAR2
ARHGEF11
Gene Name
lysophosphatidic acid receptor 2
Rho guanine nucleotide exchange factor (GEF) 11
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Endocytic Vesicle
Intracellular
Cytoplasm
Cytosol
Membrane
Molecular Function
G-protein Coupled Receptor Activity
Protein Binding
Lipid Binding
PDZ Domain Binding
Lysophosphatidic Acid Receptor Activity
G-protein Coupled Receptor Binding
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Rho Protein Signal Transduction
Cytokinesis
Regulation Of Cell Growth
Movement Of Cell Or Subcellular Component
Striated Muscle Contraction
G-protein Coupled Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Axon Guidance
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Positive Regulation Of Rho GTPase Activity
Termination Of G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
G alpha (q) signalling events
G alpha (q) signalling events
Signaling by GPCR
GPCR downstream signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Lysosphingolipid and LPA receptors
Signaling by GPCR
Signalling by NGF
Axon guidance
Semaphorin interactions
Cell death signalling via NRAGE, NRIF and NADE
p75 NTR receptor-mediated signalling
Rho GTPase cycle
GPCR downstream signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
G alpha (12/13) signalling events
Sema4D in semaphorin signaling
Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Sphingolipid levels (
22359512
)
Protein-Protein Interactions
6 interactors:
ARHGEF11
ARHGEF12
ATXN1
SLC9A3R1
SLC9A3R2
TRIP6
13 interactors:
ABCA1
CDC42
GNA12
GNA13
LPAR1
LPAR2
MAP1A
MAP1B
PLXNB1
PLXNB2
PLXNB3
RHOA
SLC1A6
Entrez ID
9170
9826
HPRD ID
05487
09302
Ensembl ID
ENSG00000064547
ENSG00000132694
Uniprot IDs
Q9HBW0
F8W8P9
O15085
PDB IDs
1HTJ
1XCG
2DLS
3KZ1
3T06
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Signaling
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Intracellular Signal Transduction
Termination Of G-protein Coupled Receptor Signaling Pathway
Termination Of Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Renal Phosphate Ion Absorption
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Negative Regulation Of Sodium:proton Antiporter Activity
Glutathione Transport
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Renal Sodium Ion Transport
Release Of Cytoplasmic Sequestered NF-kappaB
Neurotrophin Signaling Pathway
Cellular Phosphate Ion Homeostasis
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Positive Regulation Of Rho GTPase Activity
Negative Regulation Of Sodium Ion Transmembrane Transport
Regulation Of Rho GTPase Activity
G-protein Coupled Receptor Signaling Pathway
Cell Projection Organization
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Bile Acid Secretion
Regulation Of Rho Protein Signal Transduction
Oligopeptide Transport
Apoptotic Signaling Pathway
Negative Regulation Of Sodium Ion Transport
Renal Absorption
Regulation Of Proton Transport
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphate Ion Homeostasis
Signaling
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Microvillus Assembly
Axon Guidance
Negative Regulation Of Phosphorylation
Cell Communication
Regulation Of Apoptotic Process
Microvillus Organization
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Positive Regulation Of Cell Projection Organization
Positive Regulation Of Cell Morphogenesis Involved In Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Axonogenesis
Positive Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Development
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Neuron Differentiation
Regulation Of Rho Protein Signal Transduction
Regulation Of Locomotion
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Component Movement
Regulation Of Neuron Projection Development
Regulation Of Axonogenesis
Regulation Of Cell Shape
Semaphorin-plexin Signaling Pathway
Positive Regulation Of Neurogenesis
Regulation Of Cell Development
Positive Regulation Of Cell Differentiation
Apolipoprotein A-I-mediated Signaling Pathway
Rho Protein Signal Transduction
Axonogenesis
Generation Of Neurons
Signaling
Regulation Of Cell Differentiation
Regulation Of Neuron Differentiation
Cell Communication
Axon Development
Positive Regulation Of Phospholipase Activity
Anatomical Structure Morphogenesis
Neurogenesis
Cell Morphogenesis Involved In Neuron Differentiation
Cell Differentiation
Regulation Of Phospholipase Activity
Positive Regulation Of Lipase Activity
Neuron Projection Morphogenesis
Cell Projection Organization
Regulation Of Ras Protein Signal Transduction
Regulation Of Neurogenesis
Regulation Of Signal Transduction
Cell Morphogenesis Involved In Differentiation
Ossification Involved In Bone Maturation
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Bone Maturation
Tagcloud
?
aggressive
anchorage
cascade
colony
concurrent
cox
cxcl1
database
differentially
dramatically
dual
engraftment
ezh2
il
interleukin
multivariable
offer
predicted
proved
rationale
specimens
stanched
strategy
therapies
times
tnbc
tnbcs
triple
Tagcloud (Difference)
?
aggressive
anchorage
cascade
colony
concurrent
cox
cxcl1
database
differentially
dramatically
dual
engraftment
ezh2
il
interleukin
multivariable
offer
predicted
proved
rationale
specimens
stanched
strategy
therapies
times
tnbc
tnbcs
triple
Tagcloud (Intersection)
?