LPAR2 and ATXN1

Number of citations of the paper that reports this interaction (PMID 23275563)
1

Data Source:
BioGRID (two hybrid)

		LPAR2	ATXN1
Gene Name		lysophosphatidic acid receptor 2	ataxin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear RNA Export Factor Complex Nuclear Inclusion Body Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity	DNA Binding Chromatin Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association
	Biological Process	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Processing Adult Locomotory Behavior Visual Learning Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Nuclear Export Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Sphingolipid levels ( 22359512)	Amyotrophic lateral sclerosis ( 19451621) Gambling ( 22780124) Major depressive disorder ( 23377640)
Protein-Protein Interactions		6 interactors: ARHGEF11 ARHGEF12 ATXN1 SLC9A3R1 SLC9A3R2 TRIP6	252 interactors: ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAM21C FAM46A FAM46B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 HEY2 HEYL HIST1H3A HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A HYPM IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOC401442 LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUMO2 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WBSCR16 WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX
Entrez ID		9170	6310
HPRD ID		05487	03333
Ensembl ID		ENSG00000064547	ENSG00000124788
Uniprot IDs		Q9HBW0	P54253 Q96FF1
PDB IDs			1OA8 4APT 4AQP 4J2J 4J2L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Renal Sodium Ion Transport Release Of Cytoplasmic Sequestered NF-kappaB Neurotrophin Signaling Pathway Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Rho GTPase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Rho GTPase Activity G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Bile Acid Secretion Regulation Of Rho Protein Signal Transduction Oligopeptide Transport Apoptotic Signaling Pathway Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phosphate Ion Homeostasis Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Assembly Axon Guidance Negative Regulation Of Phosphorylation Cell Communication Regulation Of Apoptotic Process Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Multicellular Organismal Development Positive Regulation Of Metabolic Process Developmental Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Differentiation System Development Anatomical Structure Development Cell Differentiation Organ Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Process Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Response To Stimulus
Tagcloud ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple	akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple	akap6 atf7 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?