TAOK2 and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		TAOK2	KLHL12
Description		TAO kinase 2	kelch like family member 12
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Focal Adhesion Assembly Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways			Degradation of DVL
Drugs		Dexfosfoserine Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 30285260 29483656 28991256 25056061) Triglyceride levels ( 32154731 32203549) Waist circumference ( 31928498)
Interacting Genes		12 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		9344	59349
HPRD ID		18147	13925
Ensembl ID		ENSG00000149930	ENSG00000117153
Uniprot IDs		Q9UL54	Q53G59 Q9H7R2
PDB IDs			2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus NLRP1 Inflammasome Complex Assembly Response To Radiation Cellular Response To UV-B MAP Kinase Kinase Activity COPII Vesicle Coat Structural Constituent Of Cytoskeleton Response To UV-B Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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