CYTH3 and CNKSR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		CYTH3	CNKSR1
Gene Name		cytohesin 3	connector enhancer of kinase suppressor of Ras 1
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Gene Ontology Annotations	Cellular Component	Ruffle Trans-Golgi Network Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Phosphatidylinositol-3,4,5-trisphosphate Binding	Protein Binding, Bridging
	Biological Process	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Establishment Of Epithelial Cell Polarity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CALCOCO1 CCDC120 CNKSR1 CYTIP FRMD4B GRASP IPCEF1 SYCE1	18 interactors: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SMAD4 STK3 STK4 ZDHHC17
Entrez ID		9265	10256
HPRD ID		05469	11937
Ensembl ID		ENSG00000008256	ENSG00000142675
Uniprot IDs		B7Z2V9 O43739	Q53GM7 Q969H4
PDB IDs		4KAX	1WWV
Enriched GO Terms of Interacting Partners?			Regulation Of Signal Transduction Regulation Of Signaling Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Signaling Endocardium Development Small GTPase Mediated Signal Transduction Cell Communication Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Protein Autophosphorylation Primitive Hemopoiesis Response To Stimulus Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process
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