CYTH3 and IFI35

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CYTH3	IFI35
Description		cytohesin 3	interferon induced protein 35
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Ruffle Nucleoplasm Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Anchoring Junction	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction Positive Regulation Of Cell Adhesion Golgi Vesicle Transport Establishment Of Epithelial Cell Polarity	Macrophage Activation Involved In Immune Response Immune System Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Intra-Golgi traffic	Interferon alpha/beta signaling
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 26426971) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Shigella-associated diarrhea ( 33649051)	Coronary artery disease ( 29212778)
Interacting Genes		10 interacting genes: ARFIP2 CALCOCO1 CNKSR1 CYTIP FRMD4B IFI35 ITSN1 PIK3CA SNCA TAMALIN	12 interacting genes: BATF BCAS2 CLEC4G CYTH3 EML2 FHL2 KDM1A MAPK1 NMI PLEKHO1 TRIM55 TRIM63
Entrez ID		9265	3430
HPRD ID		05469	02844
Ensembl ID		ENSG00000008256	ENSG00000068079
Uniprot IDs		B7Z2V9 O43739	P80217
PDB IDs		4KAX 6U3E 6U3G
Enriched GO Terms of Interacting Partners?		Cell Cortex Cytoplasm Macrophage Activation Regulation Of Cellular Respiration Presynaptic Endocytosis Synaptic Vesicle Endocytosis Regulation Of Endocytosis Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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