SH2B2 and ASB6

Number of citations of the paper that reports this interaction (PMID 15231829)
17

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		SH2B2	ASB6
Gene Name		SH2B adaptor protein 2	ankyrin repeat and SOCS box containing 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane	Cytoplasm
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Identical Protein Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Nervous System Development Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of JAK-STAT Cascade Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway Brown Fat Cell Differentiation	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	6 interactors: APP FAM9B L3MBTL3 RNF41 SH2B2 TCEB1
Entrez ID		10603	140459
HPRD ID		16097	10673
Ensembl ID
Uniprot IDs		O14492	Q9NWX5
PDB IDs		1Q2H
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Peptidyl-amino Acid Modification Positive Regulation Of Signal Transduction Response To Organic Substance Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Innate Immune Response Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Proliferation Regulation Of Immune Response Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Signaling Neurotrophin TRK Receptor Signaling Pathway Defense Response Cell Communication Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Phosphorylation Response To Growth Factor Movement Of Cell Or Subcellular Component Response To Peptide Hormone Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell Activation Response To Peptide Response To Wounding Immune Response Regulation Of Immune System Process Cellular Response To Stimulus	Cell Maturation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Homeostasis Of Number Of Cells
Tagcloud ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl
Tagcloud (Difference) ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl
Tagcloud (Intersection) ?