SH2B2 and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 15767667)
83

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SH2B2	SH2B1
Description		SH2B adaptor protein 2	SH2B adaptor protein 1
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 29381148 28448500 19079261 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	19 interacting genes: CRK CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 HUNK IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		10603	25970
HPRD ID		16097	12336
Ensembl ID		ENSG00000160999	ENSG00000178188
Uniprot IDs		O14492	B3KNV5 B4DLN5 Q9NRF2
PDB IDs		1Q2H	5W3R
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Kinase Activity Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Substrate Binding Peptidyl-tyrosine Phosphorylation ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Plasma Membrane ERBB Signaling Pathway Nucleotide Binding Transferase Activity Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Neuron Differentiation Signal Transduction Phosphorylation Regulation Of Signal Transduction Cell Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Identical Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Endosome Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase Binding Cellular Developmental Process Positive Regulation Of Phosphate Metabolic Process Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation
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