SH2B2 and MCRS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH2B2	MCRS1
Description		SH2B adaptor protein 2	microspherule protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Lysosome Centrosome Cytoskeleton Nuclear Body Dendrite Ino80 Complex Centriolar Satellite Perikaryon NSL Complex MLL1 Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Telomerase Inhibitor Activity Poly(G) Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Protein Localization To Nucleolus
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	125 interacting genes: AGGF1 ARK2N AXIN2 BACH2 BEND3 BHLHA9 BHLHE40 BLM BRD8 BRMS1 BRMS1L C7orf57 C8orf34 CARD9 CATSPERT CAVIN2 CBY2 CCDC13 CCDC136 CCDC85B CCHCR1 CCNH CDCA7L CEP44 CEP70 CNTROB COIL CREB3L3 CRYAA CYSRT1 CYTIP DAXX DRAP1 DSCR9 DVL2 EGR2 ERF EVI5 FAM9A FNDC8 FSD2 FXR1 FXR2 GAS7 GCC1 GEM GIGYF1 GOLGA2 GPBP1 HMBOX1 HOOK2 IKZF1 IKZF3 IKZF4 JAKMIP1 KANK2 KAT7 KDM1A KIAA1958 KRT35 KRTAP10-7 KRTAP2-3 KRTAP2-4 KXD1 LIG4 LSM6 LZTS1 MAGEA11 MAGEA6 MAPK9 MED4 MEOX1 MFAP1 MIER2 MIER3 NAA10 NAB2 NKAPD1 NOP2 OSBPL3 PBK PBX2 PCM1 PHC2 PIBF1 PINX1 PKNOX2 PPP1R13B PRMT5 PSTPIP1 PTEN RABEP1 RALYL RARA RETREG3 RIPPLY3 SH2B2 SHANK3 SNAPC5 SP4 SRRM4 SSMEM1 SUV39H1 TADA2B TBC1D1 TERT TFAP4 TLE5 TNIP1 TNNI1 TP63 TRIM37 TRIM41 TSPYL2 UPF3B USHBP1 WASHC3 WBP11 XIAP ZBTB22 ZCCHC12 ZNF23 ZNF639 ZNF8 ZRANB1
Entrez ID		10603	10445
HPRD ID		16097	11298
Ensembl ID		ENSG00000160999	ENSG00000187778
Uniprot IDs		O14492	Q96EZ8
PDB IDs		1Q2H
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone Deacetylase Binding Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Protein-containing Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleolus Chromatin Binding Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Protein Domain Specific Binding Chromatin Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Stem Cell Proliferation Regulation Of Nervous System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Senescence Regulation Of Centromeric Sister Chromatid Cohesion MRF Binding Telomere Maintenance Via Telomerase Sequence-specific DNA Binding
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