SH2B2 and NTRK1

Number of citations of the paper that reports this interaction (PMID 9856458)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SH2B2	NTRK1
Gene Name		SH2B adaptor protein 2	neurotrophic tyrosine kinase, receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Nervous System Development Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of JAK-STAT Cascade Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway Brown Fat Cell Differentiation	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs			Amitriptyline Imatinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		10603	4914
HPRD ID		16097	01869
Ensembl ID			ENSG00000198400
Uniprot IDs		O14492	P04629
PDB IDs		1Q2H	1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Peptidyl-amino Acid Modification Positive Regulation Of Signal Transduction Response To Organic Substance Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Innate Immune Response Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Proliferation Regulation Of Immune Response Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Signaling Neurotrophin TRK Receptor Signaling Pathway Defense Response Cell Communication Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Phosphorylation Response To Growth Factor Movement Of Cell Or Subcellular Component Response To Peptide Hormone Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell Activation Response To Peptide Response To Wounding Immune Response Regulation Of Immune System Process Cellular Response To Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes tyrosyl	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trkb trkc
Tagcloud (Intersection) ?		trka