SH2B2 and NTRK1

Number of citations of the paper that reports this interaction (PubMedID 25921289)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		SH2B2	NTRK1
Description		SH2B adaptor protein 2	neurotrophic receptor tyrosine kinase 1
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane	Cytoplasm Mitochondrion Endosome Early Endosome Late Endosome Plasma Membrane Cell Surface Endosome Membrane Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Neuronal Cell Body Receptor Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Neurotrophin Receptor Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Protein Homodimerization Activity Neurotrophin Binding Nerve Growth Factor Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Axon Guidance Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Programmed Cell Death Involved In Cell Development Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development Cell Differentiation B Cell Differentiation Neuron Projection Development Response To Nutrient Levels Response To Nicotine Peptidyl-tyrosine Autophosphorylation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Neuron Apoptotic Process Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Innervation Axonogenesis Involved In Innervation Behavioral Response To Formalin Induced Pain Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Growth Factor Stimulus Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	PLC-gamma1 signalling Signalling to RAS ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling NGF-independant TRKA activation TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN PI3K/AKT activation PI3K/AKT activation Signalling to STAT3
Drugs			Amitriptyline Imatinib Regorafenib Entrectinib Fostamatinib Cenegermin Larotrectinib Pralsetinib
Diseases			Neuroblastoma Thyroid cancer
GWAS		Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)	Red cell distribution width ( 32888494)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	41 interacting genes: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 ERBB2 FRS2 FRS3 GIPC1 GRB2 HIPK2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 PTPRR RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TPTE TRAF4 TRAF6 UBB
Entrez ID		10603	4914
HPRD ID		16097	01869
Ensembl ID		ENSG00000160999	ENSG00000198400
Uniprot IDs		O14492	P04629 X5DR71
PDB IDs		1Q2H	1HE7 1SHC 1WWA 1WWW 2IFG 2N90 4AOJ 4CRP 4F0I 4GT5 4PMM 4PMP 4PMS 4PMT 4YNE 4YPS 5H3Q 5I8A 5JFS 5JFV 5JFW 5JFX 5KMI 5KMJ 5KMK 5KML 5KMM 5KMN 5KMO 5KVT 5WR7 6D1Y 6D1Z 6D20 6D22 6DKB 6DKG 6DKI 6DKW 6IQN 6J5L 6NPT 6NSP 6NSS 6PL1 6PL2 6PL3 6PL4 6PMA 6PMB 6PMC 6PME 7N3T 7VKM 7VKN 7VKO 7XAF 7XBI 8J5W 8J5X 8J61 8J63 8YTD 8YTE
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphotyrosine Residue Binding Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytosol Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Neurotrophin TRKA Receptor Binding Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Insulin Receptor Binding Neurotrophin Signaling Pathway Plasma Membrane Regulation Of Apoptotic Process Nerve Growth Factor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Response To Growth Factor Regulation Of Programmed Cell Death Intracellular Signaling Cassette Signaling Adaptor Activity Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Ephrin Receptor Binding Protein Kinase Binding Positive Regulation Of Cell Population Proliferation Regulation Of Immune Response Positive Regulation Of D-glucose Import Regulation Of Cell Adhesion Enzyme Binding Regulation Of Cellular Localization SH2 Domain Binding Insulin-like Growth Factor Receptor Binding Developmental Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Biological Quality Negative Regulation Of Programmed Cell Death
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