SH2B2 and PLEKHA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SH2B2	PLEKHA3
Description		SH2B adaptor protein 2	pleckstrin homology domain containing A3
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GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane	Golgi Membrane Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane Recycling Endosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding	Protein Binding Lipid Binding Identical Protein Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation	Receptor Recycling Endosome Organization Retrograde Transport, Endosome To Golgi
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)	Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417	8 interacting genes: DOK3 ERRFI1 MORF4L1 MRPL45 MYO15B RNMT SH2B2 TCL1B
Entrez ID		10603	65977
HPRD ID		16097	09688
Ensembl ID		ENSG00000160999	ENSG00000116095
Uniprot IDs		O14492	Q9HB20
PDB IDs		1Q2H	2KCJ 2MDX 3RCP
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
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