TFAP2A and LDLRAP1

Number of citations of the paper that reports this interaction (PMID 12221107)
50

Data Source:
HPRD (in vitro)

		TFAP2A	LDLRAP1
Gene Name		transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Intracellular Membrane-bounded Organelle	Early Endosome Cytosol Neurofilament Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane AP-1 Adaptor Complex AP-2 Adaptor Complex Axon Recycling Endosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity	Beta-amyloid Binding Phosphotyrosine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Outflow Tract Morphogenesis Keratinocyte Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Transcription From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Embryonic Body Morphogenesis Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Neural Crest Cell Development Anterior Neuropore Closure Trigeminal Nerve Development Oculomotor Nerve Formation Forebrain Neuron Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Embryonic Cranial Skeleton Morphogenesis Epidermis Morphogenesis Palate Development Lens Induction In Camera-type Eye Face Morphogenesis Bone Morphogenesis Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Basement Membrane Organization Metanephric Nephron Development Negative Regulation Of Reactive Oxygen Species Metabolic Process	Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Receptor Internalization Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process
Pathways
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		30 interactors: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CTNNB1 DEK EP300 EPN2 EPS15 GSTO2 HIP1 LDLRAP1 MAGI1 MKRN3 MYC NPM1 PPARG RB1 SP1 SRA1 SUMO4 SYT1 TP53 UBE2I WWP1 WWP2 YBX1	7 interactors: AP2B1 APP CLTC LDLR LRP2 OBFC1 TFAP2A
Entrez ID		7020	26119
HPRD ID		00128	05765
Ensembl ID		ENSG00000137203	ENSG00000157978
Uniprot IDs		P05549	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?		Cell Death Death Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Glial Cell Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Peptidase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Death Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Immune System Development Positive Regulation Of Proteolysis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated	Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor-mediated Endocytosis Vesicle-mediated Transport Steroid Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Phototransduction, Visible Light Forebrain Development Response To Radiation Retinoid Metabolic Process Diterpenoid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Visible Light Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Optic Cup Structural Organization Phototransduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Optic Vesicle Morphogenesis Oculomotor Nerve Formation Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Tooth Mineralization Negative Regulation Of Hyaluronan Biosynthetic Process Response To External Stimulus Brain Development Detection Of Abiotic Stimulus Oculomotor Nerve Development Head Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Neuron Development Central Nervous System Development Intestinal Cholesterol Absorption Anterior Neuropore Closure Nervous System Development Optic Cup Morphogenesis Involved In Camera-type Eye Development
Tagcloud ?		blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Difference) ?		blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Intersection) ?